Exposure to low-dose barium by drinking water causes hearing loss in mice

► Oral exposure to low-dose barium causes hearing loss in mice. ► Oral exposure to low-dose barium causes severe degeneration of inner ears in mice. ► Low-dose barium administered by drinking water specifically distributes to inner ears in mice. We continuously ingest barium as a general element by...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2012-10, Vol.33 (5), p.1276-1283
Hauptverfasser:	Ohgami, Nobutaka, Hori, Sohjiro, Ohgami, Kyoko, Tamura, Haruka, Tsuzuki, Toyonori, Ohnuma, Shoko, Kato, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Acoustics Animals Barium Barium - administration & dosage Barium - pharmacokinetics Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Degeneration Disease Models, Animal Dose-Response Relationship, Drug Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Evoked Potentials, Auditory, Brain Stem - drug effects Female Hearing loss Hearing Loss - chemically induced Inner ears Kidney - metabolism Kidney - pathology Lung - metabolism Lung - pathology Medical sciences Mice Mice, Inbred ICR Microscopy, Electron, Transmission Myocardium - metabolism Myocardium - pathology Neurons - pathology Neurons - ultrastructure Non tumoral diseases Oral exposure Otorhinolaryngology. Stomatology Spectrophotometry, Atomic - methods Spiral Ganglion - pathology Time Factors Tissue Distribution - drug effects Toxicology Water Pollutants, Chemical - administration & dosage Water Pollutants, Chemical - pharmacokinetics
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