Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic
Zaire Ebola virus (EBOV) is an enveloped non‐segmented negative strand RNA virus of 19 kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred i...
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| Veröffentlicht in: | Journal of medical virology 2015-06, Vol.87 (6), p.893-898 |
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| container_title | Journal of medical virology |
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| creator | Giovanetti, Marta Grifoni, Alba Lo Presti, Alessandra Cella, Eleonora Montesano, Carla Zehender, Gianguglielmo Colizzi, Vittorio Amicosante, Massimo Ciccozzi, Massimo |
| description | Zaire Ebola virus (EBOV) is an enveloped non‐segmented negative strand RNA virus of 19 kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation. J. Med. Virol. 87:893–898, 2015. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.24133 |
| format | Article |
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The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation. J. Med. 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Med. Virol</addtitle><description>Zaire Ebola virus (EBOV) is an enveloped non‐segmented negative strand RNA virus of 19 kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation. J. Med. Virol. 87:893–898, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Africa, Western - epidemiology</subject><subject>Amino acids</subject><subject>Amino Acids - genetics</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>Antibodies, Viral - immunology</subject><subject>Databases, Factual</subject><subject>Databases, Nucleic Acid</subject><subject>Datasets as Topic</subject><subject>Ebola virus</subject><subject>Ebolavirus - chemistry</subject><subject>Ebolavirus - genetics</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>evolutionary analysis</subject><subject>Filoviridae</subject><subject>Genetic Variation</subject><subject>glycoprotein</subject><subject>Glycoproteins</subject><subject>Hemorrhagic Fever, Ebola - epidemiology</subject><subject>Hemorrhagic Fever, Ebola - virology</subject><subject>Humans</subject><subject>Models, Molecular</subject><subject>Mutation</subject><subject>Selection, Genetic</subject><subject>Time Factors</subject><subject>Viral Envelope Proteins - chemistry</subject><subject>Viral Envelope Proteins - genetics</subject><subject>Viral Envelope Proteins - immunology</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhi1UBMuWQ_9AZamX9hDw-DM-AtpSqoVy4OtmOV6n9TaJt3EC3X-P6QKHSpV6msM882hmXoTeATkAQujhsr0_oBwY20ITIFoWmih4gyYEuCykBLGL9lJaEkJKTekO2qVClUyXeoJmR23oIrYuLHA7DnYIsUs4dHhWxcbi-9CPCX9v1i6u-jj43Ig1Hn54TLMc-1VY-Da4t2i7tk3y-891iq4_z65OvhTzb6dnJ0fzwnHKWVFTKLXWULESalsxzpxyBLzlVVkqZwmllqiF9EzUvhbghau8U5XiXNdcV2yKPm68eZlfo0-DaUNyvmls5-OYDEglmdBCwf-gVAIV-WtT9OEvdBnHvsuHPFGggWsmM_VpQ7k-ptT72qz60Np-bYCYpxhMjsH8iSGz75-NY9X6xSv58vcMHG6Ah9D49b9N5uv5zYuy2EyENPjfrxO2_2mkYkqY24tTcze_vOB3x3MD7BFjl531</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Giovanetti, Marta</creator><creator>Grifoni, Alba</creator><creator>Lo Presti, Alessandra</creator><creator>Cella, Eleonora</creator><creator>Montesano, Carla</creator><creator>Zehender, Gianguglielmo</creator><creator>Colizzi, Vittorio</creator><creator>Amicosante, Massimo</creator><creator>Ciccozzi, Massimo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope></search><sort><creationdate>201506</creationdate><title>Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic</title><author>Giovanetti, Marta ; Grifoni, Alba ; Lo Presti, Alessandra ; Cella, Eleonora ; Montesano, Carla ; Zehender, Gianguglielmo ; Colizzi, Vittorio ; Amicosante, Massimo ; Ciccozzi, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4243-f2189991b381fab343c7c01ea4b887ca022a07d6e35fef51e5cbec7b7449f49b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Africa, Western - epidemiology</topic><topic>Amino acids</topic><topic>Amino Acids - genetics</topic><topic>Antibodies, Neutralizing - immunology</topic><topic>Antibodies, Viral - immunology</topic><topic>Databases, Factual</topic><topic>Databases, Nucleic Acid</topic><topic>Datasets as Topic</topic><topic>Ebola virus</topic><topic>Ebolavirus - chemistry</topic><topic>Ebolavirus - genetics</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>evolutionary analysis</topic><topic>Filoviridae</topic><topic>Genetic Variation</topic><topic>glycoprotein</topic><topic>Glycoproteins</topic><topic>Hemorrhagic Fever, Ebola - epidemiology</topic><topic>Hemorrhagic Fever, Ebola - virology</topic><topic>Humans</topic><topic>Models, Molecular</topic><topic>Mutation</topic><topic>Selection, Genetic</topic><topic>Time Factors</topic><topic>Viral Envelope Proteins - chemistry</topic><topic>Viral Envelope Proteins - genetics</topic><topic>Viral Envelope Proteins - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giovanetti, Marta</creatorcontrib><creatorcontrib>Grifoni, Alba</creatorcontrib><creatorcontrib>Lo Presti, Alessandra</creatorcontrib><creatorcontrib>Cella, Eleonora</creatorcontrib><creatorcontrib>Montesano, Carla</creatorcontrib><creatorcontrib>Zehender, Gianguglielmo</creatorcontrib><creatorcontrib>Colizzi, Vittorio</creatorcontrib><creatorcontrib>Amicosante, Massimo</creatorcontrib><creatorcontrib>Ciccozzi, Massimo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giovanetti, Marta</au><au>Grifoni, Alba</au><au>Lo Presti, Alessandra</au><au>Cella, Eleonora</au><au>Montesano, Carla</au><au>Zehender, Gianguglielmo</au><au>Colizzi, Vittorio</au><au>Amicosante, Massimo</au><au>Ciccozzi, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. 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In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation. J. Med. Virol. 87:893–898, 2015. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25783989</pmid><doi>10.1002/jmv.24133</doi><tpages>6</tpages></addata></record> |
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| subjects | Africa, Western - epidemiology Amino acids Amino Acids - genetics Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Databases, Factual Databases, Nucleic Acid Datasets as Topic Ebola virus Ebolavirus - chemistry Ebolavirus - genetics Epidemics Epidemiology evolutionary analysis Filoviridae Genetic Variation glycoprotein Glycoproteins Hemorrhagic Fever, Ebola - epidemiology Hemorrhagic Fever, Ebola - virology Humans Models, Molecular Mutation Selection, Genetic Time Factors Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Virology |
| title | Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic |
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