Immune responses and protection efficacy of a recombinant swinepox virus expressing HA1 against swine H3N2 influenza virus in mice and pigs

► This is the first construction of recombinant SPV expressing HA1 of H3N2 SIV. ► The recombinant rSPV-H3 can express HA1 of H3N2 SIV in vitro. ► rSPV-H3 can induce specific humoral and cell-mediated immune responses in animals. ► Administration of rSPV-H3 provides a complete protection against H3N2...

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Veröffentlicht in:	Virus research 2012-08, Vol.167 (2), p.188-195
Hauptverfasser:	Xu, Jiarong, Huang, Dongyan, Liu, Shichao, Lin, Huixing, Zhu, Haodan, Liu, Bao, Lu, Chengping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal trial Animals antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood antigens Drug Carriers - administration & dosage Female Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins human health immune response Immunogenicity infectious diseases Influenza A virus Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza virus interferon-gamma Interferon-gamma - secretion Mice Mice, Inbred BALB C neutralization Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology pathogens Protection efficacy Recombinant swinepox virus Simian immunodeficiency virus Suipoxvirus - genetics Swine Swine H3N2 influenza virus Swine influenza virus Swinepox virus T-lymphocytes T-Lymphocytes - immunology vaccination Vaccination - methods vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Virus Shedding
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