Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies

► ICT and quercetin exhibited in vitro ER mediated estrogenic activity with a more potent interaction with ERβ. ► Prenylflavonoid glycosides did not show any in vitro estrogenic activities. ► The potency of in vitro estrogenic activity was in the order of ICT>Epi ext>ICA. ► ICA had the stronge...

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Veröffentlicht in:	Food and chemical toxicology 2012-08, Vol.50 (8), p.2751-2759
Hauptverfasser:	Kang, Hyun Ku, Choi, Yun-Ho, Kwon, Hyosuk, Lee, Sang-Bum, Kim, Dong-Hyun, Sung, Chung Ki, Park, Young In, Dong, Mi-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Epimedium Epimedium - chemistry Epimedium koreanum Estrogen Receptor Modulators - pharmacology estrogen receptors estrogenic properties Estrogenic/antiestrogenic activity Estrogens - pharmacology Female gene expression regulation glycosides Humans Icariin Icaritin In Vitro Techniques in vivo studies Medical sciences medicinal plants ovariectomy plant estrogens Plant Extracts - pharmacology quercetin Rats Rats, Sprague-Dawley Reporter gene assay reporter genes Toxicology Uterotrophic assay
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