Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach

•Requirements on ADME/TK are inconsistent within EU legislative frameworks on chemicals safety.•Regulatory risk assessors from various EU chemicals frameworks were interviewed.•Presented are resulting case studies on use of ADME/TK data in risk characterisations.•They illustrate how ADME/TK informat...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2013-12, Vol.67 (3), p.325-334
Hauptverfasser:	Bessems, Jos G.M., Geraets, Liesbeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption ADME Animals AUC Bioavailability Consumer Product Safety - legislation & jurisprudence European Union Government Regulation Guidelines as Topic Hazardous Substances - chemistry Hazardous Substances - pharmacokinetics Hazardous Substances - toxicity Health Knowledge, Attitudes, Practice Humans No-Observed-Adverse-Effect Level Nontherapeutic Human Experimentation - legislation & jurisprudence Nontherapeutic Human Experimentation - standards Risk Assessment Risk characterisation Route-to-route extrapolation Species selection Species Specificity Toxicity Tests - methods Toxicity Tests - standards Toxicokinetics
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