Using the negative exponential distribution to quantitatively review the evidence on how rapidly the excess risk of ischaemic heart disease declines following quitting smoking

► No previous review has formally modelled the decline in IHD risk following quitting smoking. ► We estimated when the excess risk becomes half that of continuing smoking (the half-life H). ► Based on 41 independent data blocks we estimated H as 4.40 (95% CI 3.26 to 5.95) years. ► Individual estimat...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2012-10, Vol.64 (1), p.51-67
Hauptverfasser:	Lee, Peter N., Fry, John S., Hamling, Jan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Half-Life Humans Ischaemic heart disease Male Meta-analysis Models, Statistical Myocardial Ischemia - epidemiology Myocardial Ischemia - etiology Myocardial Ischemia - metabolism Negative exponential distribution Quitting Reverse causation Review Risk Assessment Smoke - adverse effects Smoking Smoking - adverse effects Smoking - epidemiology Smoking - metabolism Smoking Cessation - statistics & numerical data
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