Maternal smoking in pregnancy moderates the effect of the brain-derived neurotrophic factor (BDNF) gene polymorphism on childhood IQ across multiple ages

Maternal smoking in pregnancy moderates the effect of the brain-derived neurotrophic factor (BDNF) gene polymorphism on childhood IQ across multiple ages

Maternal smoking in pregnancy has been separately linked with both lower IQ scores and epigenetic modifications of the brain-derived neurotrophic factor (BDNF) gene in offspring. The purpose of this study was to investigate whether maternal smoking exposure interacts with the BDNF single nucleotide...

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Veröffentlicht in:Intelligence (Norwood) 2014-03, Vol.43, p.47-51
Hauptverfasser: Waldie, Karen E., Grabka, Patrycja, Thompson, John M.D., Murphy, Rinki, Wall, Clare, Ferguson, Lynnette R., Mitchell, Edwin A.
Format: Artikel
Sprache:eng
Schlagworte:
BDNF
Biological and medical sciences
Brain
Child
Child development
Developmental psychology
Fundamental and applied biological sciences. Psychology
Gene–environment
Genotype
Human exposure
Maternal smoking
Polymorphism
Pregnancy
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Smoking
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Zusammenfassung:Maternal smoking in pregnancy has been separately linked with both lower IQ scores and epigenetic modifications of the brain-derived neurotrophic factor (BDNF) gene in offspring. The purpose of this study was to investigate whether maternal smoking exposure interacts with the BDNF single nucleotide polymorphism (SNP) rs6265 to affect offspring IQ across multiple ages during childhood. Participants are 546 members of a longitudinal study of 871 Caucasian infants sampled disproportionately for small for gestational age: approximately half had birthweight
ISSN:0160-2896
1873-7935
DOI:10.1016/j.intell.2013.12.006