IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the T sub(H)17 cell-iT sub(reg) cell balance

Interleukin 17 (IL-17)-producing helper T cells (T sub(H)17 cells) and CD4 super(+) inducible regulatory T cells (iT sub(reg) cells) emerge from an overlapping developmental program. In the intestines, the vitamin A metabolite retinoic acid (RA) is produced at steady state and acts as an important c...

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Veröffentlicht in:	Nature immunology 2015-03, Vol.16 (3), p.286-295
Hauptverfasser:	Basu, Rajatava, Whitley, Sarah K, Bhaumik, Suniti, Zindl, Carlene L, Schoeb, Trenton R, Benveniste, Etty N, Pear, Warren S, Hatton, Robin D, Weaver, Casey T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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