Perillyl alcohol improves functional and histological outcomes against ischemia–reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-κB in middle cerebral artery occlusion rats

Perillyl alcohol (PA) is a monoterpene found in essential oils of mints, cherries, citreous fruits and lemon grass, reported to have antioxidant and anti-inflammatory properties. However, the role of PA in stroke is still illusive. Since oxidative stress and inflammation play a pivotal role in ische...

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Veröffentlicht in:	European journal of pharmacology 2015-01, Vol.747, p.190-199
Hauptverfasser:	Tabassum, Rizwana, Vaibhav, Kumar, Shrivastava, Pallavi, Khan, Andleeb, Ahmed, Mohd. Ejaz, Ashafaq, Mohammad, Khan, M. Badruzzaman, Islam, Farah, Safhi, Mohammed M., Islam, Fakhrul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Brain - drug effects Brain - enzymology Brain - pathology Brain - physiopathology Cyclooxygenase 2 - metabolism Cytokines - metabolism Gene Expression Regulation, Enzymologic - drug effects Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Inflammation Ischemia–reperfusion Male Middle cerebral artery occlusion Monoterpenes - pharmacology Neuroprotective Agents - pharmacology NF-kappa B - metabolism Nitric Oxide Synthase Type II - metabolism Oxidative stress Oxidative Stress - drug effects Perillyl alcohol Prunus Rats Rats, Wistar Reperfusion Injury - complications
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