Development and characterization of a replicon-based phenotypic assay for assessing HCV NS4B from clinical isolates

•A replicon-based HCV NS4B phenotypic assay was developed and characterized.•Phenotypic analysis of the GT1a and GT1b NS4B clinical isolates was successful.•Substitutions at positions 94 and 105 are important residues for susceptibility.•This phenotypic assay aids in the discovery and development of...

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Veröffentlicht in:	Antiviral research 2013-11, Vol.100 (2), p.328-336
Hauptverfasser:	Rajyaguru, Sonal, Yang, Huiling, Martin, Ross, Miller, Michael D., Mo, Hongmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Cell Line Chimeric replicon Clinical isolates Drug Resistance, Viral Genetic Vectors HCV Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C - virology Hepatitis C virus Hepatocytes - virology Human viral diseases Humans Infectious diseases Medical sciences Microbial Sensitivity Tests - methods NS4B Pharmacology. Drug treatments Replicon Viral diseases Viral hepatitis Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virology - methods Virus Cultivation - methods Virus Replication
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