Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase–primase inhibitor pritelivir

•USA HSV clinical isolates are sensitive to helicase–primase inhibitor, pritelivir.•HSV-2 strains show more individual variation than HSV-1 strains.•HSV-1 strains with acyclovir resistance mutations are sensitive to pritelivir.•These data provide baseline data pre-wide exposure to helicase–primase i...

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Veröffentlicht in:	Antiviral research 2013-11, Vol.100 (2), p.297-299
Hauptverfasser:	Field, Hugh J., Huang, Meei-Li, Lay, Elizabeth M., Mickleburgh, Ian, Zimmermann, Holger, Birkmann, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - pharmacology AIC316 Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology BAY 57-1293 Biological and medical sciences DNA Helicases - antagonists & inhibitors Helicase–primase Herpes simplex virus 1 Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - isolation & purification Herpesvirus 2, Human - drug effects Herpesvirus 2, Human - isolation & purification HSV Humans Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pritelivir Pyridines - pharmacology Thiazoles - pharmacology United States Viral Plaque Assay
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