Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53

•Resveratrol and clofarabine enhances a strong cytotoxicity with increased p53 activity.•Combination treatment of resveratrol and clofarabine enhances p53 transactivation.•The combined effect of resveratrol and clofarabine on apoptosis is synergistic.•Resveratrol could be useful to increase the effi...

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Veröffentlicht in:	Food and chemical toxicology 2014-01, Vol.63, p.153-160
Hauptverfasser:	Lee, Yoon-Jin, Park, Ihl-Sung, Lee, Yong-Jin, Shim, Jung-Hyun, Cho, Moon-Kyun, Nam, Hae-Seon, Park, Ji Woong, Oh, Myung-Ho, Lee, Sang-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - pharmacology Anticarcinogenic Agents - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis Arabinonucleosides - pharmacology Base Sequence Biological and medical sciences Cell Line, Tumor Chemopotentiator Chemotherapy Clofarabine DNA Primers G1 Phase Genes, p53 Humans Medical sciences Mesothelioma Mesothelioma - drug therapy Mesothelioma - pathology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncogene Proteins - genetics p53 Pharmacology. Drug treatments Polymerase Chain Reaction Resveratrol Stilbenes - pharmacology Toxicology Tumors
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