Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes

•DON induced genotoxicity in human lymphocytes.•DON evoked oxidative stress to deplete antioxidase.•Depletion of antioxidase reduced ability of DNA repair.•Oxidative stress also up-regulated or inhibited expression of HO-1 in 6 or 24h. Deoxynivalenol (DON) is one of the most common mycotoxins. The a...

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Veröffentlicht in:	Food and chemical toxicology 2014-02, Vol.64, p.383-396
Hauptverfasser:	Yang, Wei, Yu, Miao, Fu, Juan, Bao, Wei, Wang, Di, Hao, Liping, Yao, Ping, Nüssler, Andreas K., Yan, Hong, Liu, Liegang
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Case-Control Studies Comet Assay Deoxynivalenol DNA Primers DNA repair Dose-Response Relationship, Drug Genotoxicity HO-1 Human lymphocytes Humans Lymphocytes - drug effects Medical sciences Mutagens - pharmacology Oxidative damage Oxidative Stress - drug effects Plant poisons toxicology Polymerase Chain Reaction Smoking - metabolism Toxicology Trichothecenes - pharmacology
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