Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance

Axonal maintenance is known to rely, in part, on non-cell-autonomous support from myelinating glia, but the mechanisms are still unclear. In this study, the authors show that loss of the serine/threonine kinase LKB1 in Schwann cells leads to changes in nerve metabolism and axonal degeneration, even...

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Veröffentlicht in:	Nature neuroscience 2014-10, Vol.17 (10), p.1351-1361
Hauptverfasser:	Beirowski, Bogdan, Babetto, Elisabetta, Golden, Judith P, Chen, Ying-Jr, Yang, Kui, Gross, Richard W, Patti, Gary J, Milbrandt, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14/19 14/28 14/32 38 38/1 38/39 631/378/2596/3921 631/378/2606 631/378/340 64/60 AMP-Activated Protein Kinases Animal Genetics and Genomics Animals Axons Axons - physiology Behavioral Sciences Biological Techniques Biomedicine Cell metabolism Cells, Cultured Deoxyglucose - metabolism Diabetes Diabetic neuropathy Female Genetic aspects Homeostasis In Vitro Techniques Kinases Lipids Luminescent Proteins - genetics Male Medicine Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity - genetics Mutation - genetics Myelin P0 Protein - genetics Myelin Proteolipid Protein - genetics Nerve Fibers, Myelinated - metabolism Neurobiology Neuromuscular Junction - cytology Neurons - physiology Neurosciences Peripheral Nerves - cytology Peripheral Nerves - physiology Phosphotransferases Properties Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins Schwann cells Schwann Cells - physiology
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