Targeting colon cancer cell NF-κB promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis

In a model of peritoneal metastasis in immune-competent mice, we show that nuclear factor (NF)-κB inhibition in CT26 colon cancer cells prevents metastasis. NF-κB inhibition, by stable overexpression of IκB-α super-repressor, induced differential polarization of co-cultured macrophages to an M1-like...

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Veröffentlicht in:	Oncogene 2015-03, Vol.34 (12), p.1563-1574
Hauptverfasser:	Ryan, A E, Colleran, A, O'Gorman, A, O'Flynn, L, Pindjacova, J, Lohan, P, O'Malley, G, Nosov, M, Mureau, C, Egan, L J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1504/1885/1393 631/67/322 631/67/580 631/80/86 Angiogenesis Animals Apoptosis Arginase Care and treatment CD4 antigen CD44 antigen CD8 antigen Cell Biology Cell Line, Tumor Colon cancer Colonic Neoplasms - pathology Colorectal cancer Culture Media, Conditioned Effector cells Female Gene expression Genotype & phenotype Health aspects Human Genetics Humans I-kappa B Proteins - metabolism Inflammation Interleukin 10 Internal Medicine L-selectin Lymphocytes T Macrophages Macrophages - metabolism Matrix metalloproteinase Medicine Medicine & Public Health Metalloproteinase Metastases Metastasis Mice Mice, Inbred BALB C Neoplasm Transplantation NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-κB protein Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase Oncology original-article Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary Peritoneum Phenotype Phenotypes Polarization Prevention Signal Transduction Tissue inhibitor of metalloproteinases Transcription factors Tumors
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