TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFκB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells

•TOPs inhibited iNOS and TNF-α expression through NFκB modulation in LPS-stimulated RAW 264.7 cells.•Induced HO-1 expression by TOPs treatment protected macrophages against oxidative stress-mediated cell death.•TOPs inhibited inflammation and accelerated antioxidative potential through PI3K-Akt path...

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Veröffentlicht in:	Food and chemical toxicology 2014-04, Vol.66, p.56-64
Hauptverfasser:	Park, Chung Mu, Cho, Chung Won, Song, Young Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory Antioxidants - metabolism Antioxidative Biological and medical sciences Cell Line Food toxicology Heme Oxygenase-1 - metabolism Inflammation - prevention & control Macrophages - drug effects Macrophages - enzymology Macrophages - metabolism Medical sciences Mice NF-E2-Related Factor 2 - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - physiology NFκB Nrf2 Phosphatidylinositol 3-Kinases - metabolism PI3KAkt Polysaccharides - pharmacology Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Taraxacum - chemistry Taraxacum officinale Taraxacum officinale polysaccharide Toxicology
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