Waterborne exposure of zebrafish embryos to micromole concentrations of ioxynil and diethylstilbestrol disrupts thyrocyte development

•Micromolar concentrations of waterborne IOX and DES disrupt thyrocyte embryonic development in zebrafish.•IOX and DES do not seem to directly interact with components of thyroid hormone genomic and non-genomic cellular pathways.•IOX but most notably DES disrupt thyrocyte development indirectly via...

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Veröffentlicht in:	Aquatic toxicology 2013-09, Vol.140-141, p.279-287
Hauptverfasser:	Campinho, M.A., Power, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Danio rerio Development Diethylstilbestrol Diethylstilbestrol - toxicity Embryo, Nonmammalian - drug effects Endocrine disruption fish gene expression Gene Expression Regulation - drug effects genes heart Heart - drug effects Hypothalamus - drug effects Iodobenzenes - toxicity Ioxynil messenger RNA Nitriles - toxicity NK Cell Lectin-Like Receptor Subfamily A - genetics pollutants Teleostei Thyrocytes Thyroglobulin - genetics thyroid gland Thyroid Gland - cytology Thyroid Gland - drug effects thyroid hormones Water Pollutants, Chemical - toxicity Zebrafish Zebrafish - physiology
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