Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice
► PD is a triterpenoid saponin, isolated from the root of Platycodon grandiflorum. ► We aimed to evaluate protective effect of PD on cisplatin-induced nephrotoxicity. ► The levels of oxidant and antioxidant enzymes were examined with histopathological studies. ► PD ameliorated the cisplatin induced...
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| creator | Kim, Tae-Won Song, In-Bae Lee, Hong-Ki Lim, Jong-Hwan Cho, Eun-Sang Son, Hwa-Young Park, Sang-Jin Kim, Jong-Woo Yun, Hyo-In |
| description | ► PD is a triterpenoid saponin, isolated from the root of Platycodon grandiflorum. ► We aimed to evaluate protective effect of PD on cisplatin-induced nephrotoxicity. ► The levels of oxidant and antioxidant enzymes were examined with histopathological studies. ► PD ameliorated the cisplatin induced renal injury by the reduced oxidative stress and apoptosis.
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR mice were allocated into five groups as follows: Negative control, CDDP alone and CDDP with PD (0.1, 1 and 5mg/kg) treated group. PD was given for three consecutive days before CDDP injection. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels in CDDP alone treated mice were decreased to normal range by pretreatment with PD. It also decreased nitric oxide (NO) and lipid peroxidation with increased antioxidant enzymes such as glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in PD pretreated mice. In histopathological examination, pretreatment with PD showed ameliorated renal injury such as intraluminal cast formation and epithelial desquamation. Furthermore, over-expression of nuclear factor-kappa B p65 and apoptotic cells were suppressed by PD pretreatment. Taken together, PD pretreatment might be beneficial to CDDP-induced nephrotoxicity. |
| doi_str_mv | 10.1016/j.fct.2012.05.022 |
| format | Article |
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Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR mice were allocated into five groups as follows: Negative control, CDDP alone and CDDP with PD (0.1, 1 and 5mg/kg) treated group. PD was given for three consecutive days before CDDP injection. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels in CDDP alone treated mice were decreased to normal range by pretreatment with PD. It also decreased nitric oxide (NO) and lipid peroxidation with increased antioxidant enzymes such as glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in PD pretreated mice. In histopathological examination, pretreatment with PD showed ameliorated renal injury such as intraluminal cast formation and epithelial desquamation. Furthermore, over-expression of nuclear factor-kappa B p65 and apoptotic cells were suppressed by PD pretreatment. Taken together, PD pretreatment might be beneficial to CDDP-induced nephrotoxicity.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2012.05.022</identifier><identifier>PMID: 22617354</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; antioxidants ; apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; blood ; Blood Urea Nitrogen ; Campanulaceae ; Cisplatin ; Cisplatin - toxicity ; creatinine ; Creatinine - blood ; glutathione ; Glutathione - metabolism ; glutathione peroxidase ; Glutathione Peroxidase - metabolism ; histopathology ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney Diseases - drug therapy ; Kidney Diseases - pathology ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Nephrotoxicity ; NF-kappa B ; nitric oxide ; Nitric Oxide - blood ; Oxidative Stress - drug effects ; Plant Roots - chemistry ; Platycodin D ; Platycodon - chemistry ; Platycodon grandiflorum ; protective effect ; Saponins - pharmacology ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Toxicology ; transcription factor NF-kappa B ; Triterpenes - pharmacology ; urea nitrogen</subject><ispartof>Food and chemical toxicology, 2012-12, Vol.50 (12), p.4254-4259</ispartof><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-ddf645b5c20ef644e5dae10b1f429a5052416c7d0966854918d4f6e663a73afd3</citedby><cites>FETCH-LOGICAL-c506t-ddf645b5c20ef644e5dae10b1f429a5052416c7d0966854918d4f6e663a73afd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2012.05.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26631729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22617354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Tae-Won</creatorcontrib><creatorcontrib>Song, In-Bae</creatorcontrib><creatorcontrib>Lee, Hong-Ki</creatorcontrib><creatorcontrib>Lim, Jong-Hwan</creatorcontrib><creatorcontrib>Cho, Eun-Sang</creatorcontrib><creatorcontrib>Son, Hwa-Young</creatorcontrib><creatorcontrib>Park, Sang-Jin</creatorcontrib><creatorcontrib>Kim, Jong-Woo</creatorcontrib><creatorcontrib>Yun, Hyo-In</creatorcontrib><title>Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► PD is a triterpenoid saponin, isolated from the root of Platycodon grandiflorum. ► We aimed to evaluate protective effect of PD on cisplatin-induced nephrotoxicity. ► The levels of oxidant and antioxidant enzymes were examined with histopathological studies. ► PD ameliorated the cisplatin induced renal injury by the reduced oxidative stress and apoptosis.
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR mice were allocated into five groups as follows: Negative control, CDDP alone and CDDP with PD (0.1, 1 and 5mg/kg) treated group. PD was given for three consecutive days before CDDP injection. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels in CDDP alone treated mice were decreased to normal range by pretreatment with PD. It also decreased nitric oxide (NO) and lipid peroxidation with increased antioxidant enzymes such as glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in PD pretreated mice. In histopathological examination, pretreatment with PD showed ameliorated renal injury such as intraluminal cast formation and epithelial desquamation. Furthermore, over-expression of nuclear factor-kappa B p65 and apoptotic cells were suppressed by PD pretreatment. Taken together, PD pretreatment might be beneficial to CDDP-induced nephrotoxicity.</description><subject>Animals</subject><subject>antioxidants</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Blood Urea Nitrogen</subject><subject>Campanulaceae</subject><subject>Cisplatin</subject><subject>Cisplatin - toxicity</subject><subject>creatinine</subject><subject>Creatinine - blood</subject><subject>glutathione</subject><subject>Glutathione - metabolism</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>histopathology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - drug therapy</subject><subject>Kidney Diseases - pathology</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Nephrotoxicity</subject><subject>NF-kappa B</subject><subject>nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Roots - chemistry</subject><subject>Platycodin D</subject><subject>Platycodon - chemistry</subject><subject>Platycodon grandiflorum</subject><subject>protective effect</subject><subject>Saponins - pharmacology</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Toxicology</subject><subject>transcription factor NF-kappa B</subject><subject>Triterpenes - pharmacology</subject><subject>urea nitrogen</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EokvhB3CBXJA4kGA7sb1RT6h8SpVAgp4trz0uXiV2sB3U_fdMtVu4cfJI87zjVw8hzxntGGXy7b7ztnacMt5R0VHOH5AN26q-lb1gD8mGcrVt5cjEGXlSyp5SqpiSj8kZ55KpXgwbcvttMvVgkwuxef-mMU3NoUJeIKbgmmKWFCKufE5zc4-m2NxkE13wU8rrjKkZppCyqVAaG8qCXIhtiG614JoIy8-caroNNtRDg9fmYOEpeeTNVODZ6T0n1x8__Lj83F59_fTl8t1VawWVtXXOy0HshOUUcBpAOAOM7pgf-GgEFXxg0ipHRym3YhjZ1g1egpS9Ub3xrj8nr493l5x-rVCqnkOxME0mQlqLZlLJHnODQpQdUZtTKRm8XnKYTT5oRvWdcL3XKFzfCddUaBSOmRen8-tuBvc3cW8YgVcnwBRrJo_iUNE_DpsyxUfkXh45b5I2NxmZ6-_4k6AU9z3vkbg4EoC6fgfIutgAERWHDFjLpfCfon8Alz6o5g</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Kim, Tae-Won</creator><creator>Song, In-Bae</creator><creator>Lee, Hong-Ki</creator><creator>Lim, Jong-Hwan</creator><creator>Cho, Eun-Sang</creator><creator>Son, Hwa-Young</creator><creator>Park, Sang-Jin</creator><creator>Kim, Jong-Woo</creator><creator>Yun, Hyo-In</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20121201</creationdate><title>Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice</title><author>Kim, Tae-Won ; Song, In-Bae ; Lee, Hong-Ki ; Lim, Jong-Hwan ; Cho, Eun-Sang ; Son, Hwa-Young ; Park, Sang-Jin ; Kim, Jong-Woo ; Yun, Hyo-In</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-ddf645b5c20ef644e5dae10b1f429a5052416c7d0966854918d4f6e663a73afd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>antioxidants</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Blood Urea Nitrogen</topic><topic>Campanulaceae</topic><topic>Cisplatin</topic><topic>Cisplatin - toxicity</topic><topic>creatinine</topic><topic>Creatinine - blood</topic><topic>glutathione</topic><topic>Glutathione - metabolism</topic><topic>glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>histopathology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - drug therapy</topic><topic>Kidney Diseases - pathology</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Nephrotoxicity</topic><topic>NF-kappa B</topic><topic>nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Roots - chemistry</topic><topic>Platycodin D</topic><topic>Platycodon - chemistry</topic><topic>Platycodon grandiflorum</topic><topic>protective effect</topic><topic>Saponins - pharmacology</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Toxicology</topic><topic>transcription factor NF-kappa B</topic><topic>Triterpenes - pharmacology</topic><topic>urea nitrogen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Tae-Won</creatorcontrib><creatorcontrib>Song, In-Bae</creatorcontrib><creatorcontrib>Lee, Hong-Ki</creatorcontrib><creatorcontrib>Lim, Jong-Hwan</creatorcontrib><creatorcontrib>Cho, Eun-Sang</creatorcontrib><creatorcontrib>Son, Hwa-Young</creatorcontrib><creatorcontrib>Park, Sang-Jin</creatorcontrib><creatorcontrib>Kim, Jong-Woo</creatorcontrib><creatorcontrib>Yun, Hyo-In</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Tae-Won</au><au>Song, In-Bae</au><au>Lee, Hong-Ki</au><au>Lim, Jong-Hwan</au><au>Cho, Eun-Sang</au><au>Son, Hwa-Young</au><au>Park, Sang-Jin</au><au>Kim, Jong-Woo</au><au>Yun, Hyo-In</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>50</volume><issue>12</issue><spage>4254</spage><epage>4259</epage><pages>4254-4259</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>► PD is a triterpenoid saponin, isolated from the root of Platycodon grandiflorum. ► We aimed to evaluate protective effect of PD on cisplatin-induced nephrotoxicity. ► The levels of oxidant and antioxidant enzymes were examined with histopathological studies. ► PD ameliorated the cisplatin induced renal injury by the reduced oxidative stress and apoptosis.
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR mice were allocated into five groups as follows: Negative control, CDDP alone and CDDP with PD (0.1, 1 and 5mg/kg) treated group. PD was given for three consecutive days before CDDP injection. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels in CDDP alone treated mice were decreased to normal range by pretreatment with PD. It also decreased nitric oxide (NO) and lipid peroxidation with increased antioxidant enzymes such as glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in PD pretreated mice. In histopathological examination, pretreatment with PD showed ameliorated renal injury such as intraluminal cast formation and epithelial desquamation. Furthermore, over-expression of nuclear factor-kappa B p65 and apoptotic cells were suppressed by PD pretreatment. Taken together, PD pretreatment might be beneficial to CDDP-induced nephrotoxicity.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>22617354</pmid><doi>10.1016/j.fct.2012.05.022</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals antioxidants apoptosis Apoptosis - drug effects Biological and medical sciences blood Blood Urea Nitrogen Campanulaceae Cisplatin Cisplatin - toxicity creatinine Creatinine - blood glutathione Glutathione - metabolism glutathione peroxidase Glutathione Peroxidase - metabolism histopathology Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - drug therapy Kidney Diseases - pathology lipid peroxidation Lipid Peroxidation - drug effects Male Medical sciences Mice Mice, Inbred ICR Nephrotoxicity NF-kappa B nitric oxide Nitric Oxide - blood Oxidative Stress - drug effects Plant Roots - chemistry Platycodin D Platycodon - chemistry Platycodon grandiflorum protective effect Saponins - pharmacology superoxide dismutase Superoxide Dismutase - metabolism Toxicology transcription factor NF-kappa B Triterpenes - pharmacology urea nitrogen |
| title | Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice |
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