The activation of p38 and JNK by ROS, contribute to OLO-2-mediated intrinsic apoptosis in human hepatocellular carcinoma cells

[Display omitted] •OLO-2 inhibited hepatocellular carcinoma cell proliferation but not normal human hepatic cell.•OLO-2 specifically induced apoptosis in hepatocellular carcinoma cell.•OLO-2 induced mitochondrial apoptosis was accompanied by the activation of caspase 3/9 and the nuclear translocatio...

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Veröffentlicht in:	Food and chemical toxicology 2014-01, Vol.63, p.38-47
Hauptverfasser:	Zhang, Zhenzhen, Zhang, Chao, Ding, Ye, Zhao, Qian, Yang, Lifang, Ling, Jingjing, Liu, Ling, Ji, Hui, Zhang, Yihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cytotoxic Enzyme Activation Enzyme Activators - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Human HCC cells Humans Liver Neoplasms - enzymology Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas MAP Kinase Kinase 4 - metabolism Medical sciences Membrane Potential, Mitochondrial - drug effects Mitochondria Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology OLO-2 p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Reactive Oxygen Species - metabolism Toxicology Tumors
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