Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers
► Curcumin inhibits cell growth and metastasis of human bladder cancer cells 5637. ► Curcumin induces HO-1 mRNA and protein expression in bladder cancer cells. ► HO-1 knockdown or inhibition enhances curcumin-inhibited cancer cell invasion. ► Curcumin induces HO-1 expression in the lung and bladder...
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| creator | Wu, Szu-Yuan Lee, Ying-Ray Huang, Chin-Chin Li, Yi-Zhen Chang, Yi-Sheng Yang, Chu-Yi Wu, Jiann-Der Liu, Yi-Wen |
| description | ► Curcumin inhibits cell growth and metastasis of human bladder cancer cells 5637. ► Curcumin induces HO-1 mRNA and protein expression in bladder cancer cells. ► HO-1 knockdown or inhibition enhances curcumin-inhibited cancer cell invasion. ► Curcumin induces HO-1 expression in the lung and bladder tumor tissue in vivo. ► HO-1 inhibitor should be suggested to enhance the anti-cancer effect of curcumin.
Some phytochemicals with the characteristics of cytotoxicity and anti-metastasis has generated intense interest among the invasive cancer study. Curcumin, one of these anti-cancer phytochemicals, has been reported to induce the cytoprotective enzyme heme oxygenase-1 expression. Since heme oxygenase-1 has been suggested to enhance cancer cell invasion, we investigated the anti-invasive effect of curcumin when heme oxygenase-1 was knocked down in vitro, and the heme oxygenase-1 expression after curcumin treatment in vivo. Curcumin inhibited cell viability and the MMP-2/9 activities of human bladder cancer cells. At 10μM, curcumin inhibited cell viability and cell invasive activity by 15% and 40%, respectively. Ten micrometer curcumin increased the intracellular reactive oxygen species concentration and heme oxygenase-1 protein and mRNA expression in bladder cancer cells. The anti-invasive activity of curcumin was elevated when heme oxygenase-1 was knocked down by siRNA or inhibited by pharmacological inhibitor. In vivo, curcumin induced heme oxygenase-1 protein expression in the lung tissue of murine lung metastasis tumor model and in the bladder tissue of murine orthotopic bladder tumor model. Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin. |
| doi_str_mv | 10.1016/j.fct.2012.06.045 |
| format | Article |
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Some phytochemicals with the characteristics of cytotoxicity and anti-metastasis has generated intense interest among the invasive cancer study. Curcumin, one of these anti-cancer phytochemicals, has been reported to induce the cytoprotective enzyme heme oxygenase-1 expression. Since heme oxygenase-1 has been suggested to enhance cancer cell invasion, we investigated the anti-invasive effect of curcumin when heme oxygenase-1 was knocked down in vitro, and the heme oxygenase-1 expression after curcumin treatment in vivo. Curcumin inhibited cell viability and the MMP-2/9 activities of human bladder cancer cells. At 10μM, curcumin inhibited cell viability and cell invasive activity by 15% and 40%, respectively. Ten micrometer curcumin increased the intracellular reactive oxygen species concentration and heme oxygenase-1 protein and mRNA expression in bladder cancer cells. The anti-invasive activity of curcumin was elevated when heme oxygenase-1 was knocked down by siRNA or inhibited by pharmacological inhibitor. In vivo, curcumin induced heme oxygenase-1 protein expression in the lung tissue of murine lung metastasis tumor model and in the bladder tissue of murine orthotopic bladder tumor model. Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2012.06.045</identifier><identifier>PMID: 22771723</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal model ; Animals ; anticarcinogenic activity ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; bladder ; Bladder cancer ; cell invasion ; Cell Line, Tumor ; cell viability ; Curcumin ; Curcumin - pharmacology ; cytotoxicity ; Female ; gene expression ; Gene Expression Regulation, Enzymologic ; Gene Knockdown Techniques ; heme oxygenase (biliverdin-producing) ; Heme oxygenase-1 ; Heme Oxygenase-1 - metabolism ; Humans ; Invasion ; Lung Neoplasms ; Medical sciences ; messenger RNA ; metastasis ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; neoplasm cells ; Neoplasm Invasiveness ; Nephrology. Urinary tract diseases ; phytopharmaceuticals ; protein synthesis ; Reactive Oxygen Species ; small interfering RNA ; therapeutics ; toxicology ; Tumors of the urinary system ; urinary bladder neoplasms ; Urinary Bladder Neoplasms - drug therapy ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>Food and chemical toxicology, 2012-10, Vol.50 (10), p.3530-3536</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-d807f34d4ef41a76988ee9a8144f8460935a3041d9fce06d7cb3c0c2c43547273</citedby><cites>FETCH-LOGICAL-c440t-d807f34d4ef41a76988ee9a8144f8460935a3041d9fce06d7cb3c0c2c43547273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2012.06.045$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26418818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22771723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Szu-Yuan</creatorcontrib><creatorcontrib>Lee, Ying-Ray</creatorcontrib><creatorcontrib>Huang, Chin-Chin</creatorcontrib><creatorcontrib>Li, Yi-Zhen</creatorcontrib><creatorcontrib>Chang, Yi-Sheng</creatorcontrib><creatorcontrib>Yang, Chu-Yi</creatorcontrib><creatorcontrib>Wu, Jiann-Der</creatorcontrib><creatorcontrib>Liu, Yi-Wen</creatorcontrib><title>Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► Curcumin inhibits cell growth and metastasis of human bladder cancer cells 5637. ► Curcumin induces HO-1 mRNA and protein expression in bladder cancer cells. ► HO-1 knockdown or inhibition enhances curcumin-inhibited cancer cell invasion. ► Curcumin induces HO-1 expression in the lung and bladder tumor tissue in vivo. ► HO-1 inhibitor should be suggested to enhance the anti-cancer effect of curcumin.
Some phytochemicals with the characteristics of cytotoxicity and anti-metastasis has generated intense interest among the invasive cancer study. Curcumin, one of these anti-cancer phytochemicals, has been reported to induce the cytoprotective enzyme heme oxygenase-1 expression. Since heme oxygenase-1 has been suggested to enhance cancer cell invasion, we investigated the anti-invasive effect of curcumin when heme oxygenase-1 was knocked down in vitro, and the heme oxygenase-1 expression after curcumin treatment in vivo. Curcumin inhibited cell viability and the MMP-2/9 activities of human bladder cancer cells. At 10μM, curcumin inhibited cell viability and cell invasive activity by 15% and 40%, respectively. Ten micrometer curcumin increased the intracellular reactive oxygen species concentration and heme oxygenase-1 protein and mRNA expression in bladder cancer cells. The anti-invasive activity of curcumin was elevated when heme oxygenase-1 was knocked down by siRNA or inhibited by pharmacological inhibitor. In vivo, curcumin induced heme oxygenase-1 protein expression in the lung tissue of murine lung metastasis tumor model and in the bladder tissue of murine orthotopic bladder tumor model. Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin.</description><subject>Animal model</subject><subject>Animals</subject><subject>anticarcinogenic activity</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>bladder</subject><subject>Bladder cancer</subject><subject>cell invasion</subject><subject>Cell Line, Tumor</subject><subject>cell viability</subject><subject>Curcumin</subject><subject>Curcumin - pharmacology</subject><subject>cytotoxicity</subject><subject>Female</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Knockdown Techniques</subject><subject>heme oxygenase (biliverdin-producing)</subject><subject>Heme oxygenase-1</subject><subject>Heme Oxygenase-1 - metabolism</subject><subject>Humans</subject><subject>Invasion</subject><subject>Lung Neoplasms</subject><subject>Medical sciences</subject><subject>messenger RNA</subject><subject>metastasis</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Nude</subject><subject>neoplasm cells</subject><subject>Neoplasm Invasiveness</subject><subject>Nephrology. Urinary tract diseases</subject><subject>phytopharmaceuticals</subject><subject>protein synthesis</subject><subject>Reactive Oxygen Species</subject><subject>small interfering RNA</subject><subject>therapeutics</subject><subject>toxicology</subject><subject>Tumors of the urinary system</subject><subject>urinary bladder neoplasms</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2PFCEQhonRuOPqD_CiXEy8dFt000DH02biV7KJB90zYaAYmfSX0L3Z-ffS6VFveoIUT71U6iHkJYOSARPvTqW3c1kBq0oQJfDmEdkxJetC1A17THZQSVWIljVX5FlKJwCQTIqn5KqqZL5V9Y5M-yXapQ9DEQa3WHT0B_ZIx4fzEQeTsGAUH6aIKYVxoFNnzokaOuDRzOEeaRw7pH6MNMy5PsyhsGawGCl6j3amYaCHzjiXK9tDek6eeNMlfHE5r8ndxw_f95-L26-fvuxvbgvLOcyFUyB9zR1Hz5mRolUKsTWKce4VF9DWjamBM9d6iyCctIfagq0srxsuK1lfk7db7hTHnwumWfchWew6M-C4JM2EFDVXUqr_oyC5FKJp1lS2oTaOKUX0eoqhN_GcIb060SednejViQahs5Pc8-oSvxx6dH86fkvIwJsLYJI1nY95UyH95QRnSrF1ztcb582ozTFm5u5b_qkByDkVrMT7jcC82fuAUScbMO_dhZh1aDeGfwz6C4nfsiY</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Wu, Szu-Yuan</creator><creator>Lee, Ying-Ray</creator><creator>Huang, Chin-Chin</creator><creator>Li, Yi-Zhen</creator><creator>Chang, Yi-Sheng</creator><creator>Yang, Chu-Yi</creator><creator>Wu, Jiann-Der</creator><creator>Liu, Yi-Wen</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20121001</creationdate><title>Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers</title><author>Wu, Szu-Yuan ; Lee, Ying-Ray ; Huang, Chin-Chin ; Li, Yi-Zhen ; Chang, Yi-Sheng ; Yang, Chu-Yi ; Wu, Jiann-Der ; Liu, Yi-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-d807f34d4ef41a76988ee9a8144f8460935a3041d9fce06d7cb3c0c2c43547273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal model</topic><topic>Animals</topic><topic>anticarcinogenic activity</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>bladder</topic><topic>Bladder cancer</topic><topic>cell invasion</topic><topic>Cell Line, Tumor</topic><topic>cell viability</topic><topic>Curcumin</topic><topic>Curcumin - pharmacology</topic><topic>cytotoxicity</topic><topic>Female</topic><topic>gene expression</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Knockdown Techniques</topic><topic>heme oxygenase (biliverdin-producing)</topic><topic>Heme oxygenase-1</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>Humans</topic><topic>Invasion</topic><topic>Lung Neoplasms</topic><topic>Medical sciences</topic><topic>messenger RNA</topic><topic>metastasis</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Nude</topic><topic>neoplasm cells</topic><topic>Neoplasm Invasiveness</topic><topic>Nephrology. Urinary tract diseases</topic><topic>phytopharmaceuticals</topic><topic>protein synthesis</topic><topic>Reactive Oxygen Species</topic><topic>small interfering RNA</topic><topic>therapeutics</topic><topic>toxicology</topic><topic>Tumors of the urinary system</topic><topic>urinary bladder neoplasms</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Szu-Yuan</creatorcontrib><creatorcontrib>Lee, Ying-Ray</creatorcontrib><creatorcontrib>Huang, Chin-Chin</creatorcontrib><creatorcontrib>Li, Yi-Zhen</creatorcontrib><creatorcontrib>Chang, Yi-Sheng</creatorcontrib><creatorcontrib>Yang, Chu-Yi</creatorcontrib><creatorcontrib>Wu, Jiann-Der</creatorcontrib><creatorcontrib>Liu, Yi-Wen</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Szu-Yuan</au><au>Lee, Ying-Ray</au><au>Huang, Chin-Chin</au><au>Li, Yi-Zhen</au><au>Chang, Yi-Sheng</au><au>Yang, Chu-Yi</au><au>Wu, Jiann-Der</au><au>Liu, Yi-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>50</volume><issue>10</issue><spage>3530</spage><epage>3536</epage><pages>3530-3536</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>► Curcumin inhibits cell growth and metastasis of human bladder cancer cells 5637. ► Curcumin induces HO-1 mRNA and protein expression in bladder cancer cells. ► HO-1 knockdown or inhibition enhances curcumin-inhibited cancer cell invasion. ► Curcumin induces HO-1 expression in the lung and bladder tumor tissue in vivo. ► HO-1 inhibitor should be suggested to enhance the anti-cancer effect of curcumin.
Some phytochemicals with the characteristics of cytotoxicity and anti-metastasis has generated intense interest among the invasive cancer study. Curcumin, one of these anti-cancer phytochemicals, has been reported to induce the cytoprotective enzyme heme oxygenase-1 expression. Since heme oxygenase-1 has been suggested to enhance cancer cell invasion, we investigated the anti-invasive effect of curcumin when heme oxygenase-1 was knocked down in vitro, and the heme oxygenase-1 expression after curcumin treatment in vivo. Curcumin inhibited cell viability and the MMP-2/9 activities of human bladder cancer cells. At 10μM, curcumin inhibited cell viability and cell invasive activity by 15% and 40%, respectively. Ten micrometer curcumin increased the intracellular reactive oxygen species concentration and heme oxygenase-1 protein and mRNA expression in bladder cancer cells. The anti-invasive activity of curcumin was elevated when heme oxygenase-1 was knocked down by siRNA or inhibited by pharmacological inhibitor. In vivo, curcumin induced heme oxygenase-1 protein expression in the lung tissue of murine lung metastasis tumor model and in the bladder tissue of murine orthotopic bladder tumor model. Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>22771723</pmid><doi>10.1016/j.fct.2012.06.045</doi><tpages>7</tpages></addata></record> |
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| subjects | Animal model Animals anticarcinogenic activity Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences bladder Bladder cancer cell invasion Cell Line, Tumor cell viability Curcumin Curcumin - pharmacology cytotoxicity Female gene expression Gene Expression Regulation, Enzymologic Gene Knockdown Techniques heme oxygenase (biliverdin-producing) Heme oxygenase-1 Heme Oxygenase-1 - metabolism Humans Invasion Lung Neoplasms Medical sciences messenger RNA metastasis Mice Mice, Inbred C57BL Mice, Nude neoplasm cells Neoplasm Invasiveness Nephrology. Urinary tract diseases phytopharmaceuticals protein synthesis Reactive Oxygen Species small interfering RNA therapeutics toxicology Tumors of the urinary system urinary bladder neoplasms Urinary Bladder Neoplasms - drug therapy Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
| title | Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers |
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