Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells

Lycium barbarum polysaccharides (LBP) have been shown to play a variety of immune-modulatory functions which include activation of T and B cells. Follicular helper T (Tfh) cells are now recognized as a subset of helper T cells which regulate the multiple stages of B cell maturation and function. In...

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Veröffentlicht in:Veterinary immunology and immunopathology 2014-03, Vol.158 (1-2), p.98-104
Hauptverfasser: Su, Chun-xia, Duan, Xiang-guo, Liang, Li-jun, Feng-Wang, Zheng, Jie, Fu, Xue-Yan, Yan, Ya-mei, Ling-Huang, Wang, Ning-ping
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Sprache:eng
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Zusammenfassung:Lycium barbarum polysaccharides (LBP) have been shown to play a variety of immune-modulatory functions which include activation of T and B cells. Follicular helper T (Tfh) cells are now recognized as a subset of helper T cells which regulate the multiple stages of B cell maturation and function. In our current study, we found that LBP were able to activate CXCR5+PD-1+ Tfh cells and induce IL-21 secretion. At the same time LBP also promoted the formation of germinal centers (GC) and production of GL-7+B220+GC B cells. LBP as an adjuvant could increase generation of rAd5VP1-induced Tfh cells. Our results indicate that LBP might enhance T cell-dependent Ab responses by acting as an adjuvant for the generation of Tfh cells. Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects.
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2013.05.006