Comparative analysis of genetic toxicity of antiretroviral combinations in somatic cells of Drosophila melanogaster

► All NRTI combinations increased the frequencies of induction of mutant spots. ► Mitotic recombination was the major event induced by AZT+ddI and AZT+3TC. ► AZT+d4T showed a large discrepancy between recombination and mutation percentages. ► 3TC and d4T produced antagonism effects in combination wi...

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Veröffentlicht in:	Food and chemical toxicology 2013-03, Vol.53, p.299-309
Hauptverfasser:	Guimarães, N.N., Silva, C.J., de Andrade, H.H.R., Dihl, R.R., Lehmann, M., Cunha, K.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3TC Animals Anti-HIV Agents - adverse effects antiretroviral agents Antiviral Agents - adverse effects AZT Biological and medical sciences CD4 Lymphocyte Count d4T ddI Didanosine - adverse effects DNA damage DNA Damage - drug effects Dose-Response Relationship, Drug Drosophila melanogaster Drosophila melanogaster - drug effects Drosophila melanogaster - metabolism Drug Combinations drugs Female genotoxicity Lamivudine - adverse effects Male Medical sciences Mitosis mutants Mutation NRTI nucleosides Recombinant Proteins risk SMART somatic cells synergism therapeutics Toxicology viremia Wings, Animal - drug effects Zidovudine - adverse effects
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