Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice

► A novel polysaccharide–protein complex from Scolopendra subspinipes mutilans (SPPC). ► SPPC suppressed the growth of sarcoma S180 and hepatoma H22 in vivo. ► SPPC remarkably enhanced antitumor immune responses in S180-bearing mice. ► SPPC inhibited arachidonic acid-metabolic pathways in tumor-asso...

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Veröffentlicht in:	Food and chemical toxicology 2012-08, Vol.50 (8), p.2648-2655
Hauptverfasser:	Zhao, Haixia, Li, Ying, Wang, Yuzhong, Zhang, Jing, Ouyang, Xiaoming, Peng, Renxiu, Yang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Antitumor arachidonic acid Biological and medical sciences Catalysis CD4-positive T-lymphocytes Cell Line, Tumor Cell Proliferation - drug effects cytotoxic T-lymphocytes Diterpene Alkaloids Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry enzymes gene expression hepatoma immune response immunomodulation Immunostimulatory activity interleukin-10 Interleukin-10 - metabolism Lymphocyte Subsets macrophages Medical sciences messenger RNA Mice natural killer cells Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Oriental traditional medicine Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Proteins - pharmacology Polysaccharides - pharmacology Polysaccharide–protein complex sarcoma Scolopendra Scolopendra subspinipes mutilans L. Koch Toxicology transforming growth factor beta Transforming Growth Factor beta - metabolism
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