Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice
► A novel polysaccharide–protein complex from Scolopendra subspinipes mutilans (SPPC). ► SPPC suppressed the growth of sarcoma S180 and hepatoma H22 in vivo. ► SPPC remarkably enhanced antitumor immune responses in S180-bearing mice. ► SPPC inhibited arachidonic acid-metabolic pathways in tumor-asso...
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| creator | Zhao, Haixia Li, Ying Wang, Yuzhong Zhang, Jing Ouyang, Xiaoming Peng, Renxiu Yang, Jing |
| description | ► A novel polysaccharide–protein complex from Scolopendra subspinipes mutilans (SPPC). ► SPPC suppressed the growth of sarcoma S180 and hepatoma H22 in vivo. ► SPPC remarkably enhanced antitumor immune responses in S180-bearing mice. ► SPPC inhibited arachidonic acid-metabolic pathways in tumor-associated macrophages. ► SPPC could act as an anti-tumor agent with immunomodulatory activity.
Scolopendra subspinipes mutilans L. Koch has been used for cancer treatment in traditional Chinese medicine for hundreds of years. In this study, the effects of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch (SPPC) on the tumor growth and immune function were assessed in sarcoma S180 and hepatoma H22 bearing mice. Results showed that SPPC significantly inhibited the growth of S180 transplanted in mice and prolonged the survival time of H22- bearing mice. In S180-bearing mice, it promoted specific and nonspecific immune response as evidenced by enhancing the activities of natural killer (NK) cells, cytotoxic T lymphocytes (CTL) and the ratio of Th1/Th2 cytokines, and increasing the percentages of CD4+ T cells, B cells and NK cells. Furthermore, SPPC not only significantly inhibited mRNA expression and production of the immunosuppressive cytokines (IL-10 and TGF-β), but also diminished arachidonic acid (AA)-metabolizing enzymes (COX-2 and CYP4A) and their products (PGE2 and 20-HETE) in tumor-associated macrophages (TAMs). Taken together, our results indicate that SPPC inhibits tumor growth in vivo by improving antitumor immune responses at least partly via downregulating AA-metabolic pathways in TAMs, and could act as an anti-tumor agent with immunomodulatory activity. |
| doi_str_mv | 10.1016/j.fct.2012.05.018 |
| format | Article |
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Scolopendra subspinipes mutilans L. Koch has been used for cancer treatment in traditional Chinese medicine for hundreds of years. In this study, the effects of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch (SPPC) on the tumor growth and immune function were assessed in sarcoma S180 and hepatoma H22 bearing mice. Results showed that SPPC significantly inhibited the growth of S180 transplanted in mice and prolonged the survival time of H22- bearing mice. In S180-bearing mice, it promoted specific and nonspecific immune response as evidenced by enhancing the activities of natural killer (NK) cells, cytotoxic T lymphocytes (CTL) and the ratio of Th1/Th2 cytokines, and increasing the percentages of CD4+ T cells, B cells and NK cells. Furthermore, SPPC not only significantly inhibited mRNA expression and production of the immunosuppressive cytokines (IL-10 and TGF-β), but also diminished arachidonic acid (AA)-metabolizing enzymes (COX-2 and CYP4A) and their products (PGE2 and 20-HETE) in tumor-associated macrophages (TAMs). Taken together, our results indicate that SPPC inhibits tumor growth in vivo by improving antitumor immune responses at least partly via downregulating AA-metabolic pathways in TAMs, and could act as an anti-tumor agent with immunomodulatory activity.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2012.05.018</identifier><identifier>PMID: 22613217</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - pharmacology ; Animals ; antineoplastic agents ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Antitumor ; arachidonic acid ; Biological and medical sciences ; Catalysis ; CD4-positive T-lymphocytes ; Cell Line, Tumor ; Cell Proliferation - drug effects ; cytotoxic T-lymphocytes ; Diterpene Alkaloids ; Drug Screening Assays, Antitumor ; Drugs, Chinese Herbal - chemistry ; enzymes ; gene expression ; hepatoma ; immune response ; immunomodulation ; Immunostimulatory activity ; interleukin-10 ; Interleukin-10 - metabolism ; Lymphocyte Subsets ; macrophages ; Medical sciences ; messenger RNA ; Mice ; natural killer cells ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - pathology ; Oriental traditional medicine ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Proteins - pharmacology ; Polysaccharides - pharmacology ; Polysaccharide–protein complex ; sarcoma ; Scolopendra ; Scolopendra subspinipes mutilans L. Koch ; Toxicology ; transforming growth factor beta ; Transforming Growth Factor beta - metabolism</subject><ispartof>Food and chemical toxicology, 2012-08, Vol.50 (8), p.2648-2655</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-2eccec6200aa15fe0582bf8dcc1385eb31b8a92bc427b7e8032c4aa00d9fde753</citedby><cites>FETCH-LOGICAL-c440t-2eccec6200aa15fe0582bf8dcc1385eb31b8a92bc427b7e8032c4aa00d9fde753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691512003602$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26207986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22613217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Haixia</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Wang, Yuzhong</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Ouyang, Xiaoming</creatorcontrib><creatorcontrib>Peng, Renxiu</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><title>Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► A novel polysaccharide–protein complex from Scolopendra subspinipes mutilans (SPPC). ► SPPC suppressed the growth of sarcoma S180 and hepatoma H22 in vivo. ► SPPC remarkably enhanced antitumor immune responses in S180-bearing mice. ► SPPC inhibited arachidonic acid-metabolic pathways in tumor-associated macrophages. ► SPPC could act as an anti-tumor agent with immunomodulatory activity.
Scolopendra subspinipes mutilans L. Koch has been used for cancer treatment in traditional Chinese medicine for hundreds of years. In this study, the effects of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch (SPPC) on the tumor growth and immune function were assessed in sarcoma S180 and hepatoma H22 bearing mice. Results showed that SPPC significantly inhibited the growth of S180 transplanted in mice and prolonged the survival time of H22- bearing mice. In S180-bearing mice, it promoted specific and nonspecific immune response as evidenced by enhancing the activities of natural killer (NK) cells, cytotoxic T lymphocytes (CTL) and the ratio of Th1/Th2 cytokines, and increasing the percentages of CD4+ T cells, B cells and NK cells. Furthermore, SPPC not only significantly inhibited mRNA expression and production of the immunosuppressive cytokines (IL-10 and TGF-β), but also diminished arachidonic acid (AA)-metabolizing enzymes (COX-2 and CYP4A) and their products (PGE2 and 20-HETE) in tumor-associated macrophages (TAMs). Taken together, our results indicate that SPPC inhibits tumor growth in vivo by improving antitumor immune responses at least partly via downregulating AA-metabolic pathways in TAMs, and could act as an anti-tumor agent with immunomodulatory activity.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Antitumor</subject><subject>arachidonic acid</subject><subject>Biological and medical sciences</subject><subject>Catalysis</subject><subject>CD4-positive T-lymphocytes</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>cytotoxic T-lymphocytes</subject><subject>Diterpene Alkaloids</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>enzymes</subject><subject>gene expression</subject><subject>hepatoma</subject><subject>immune response</subject><subject>immunomodulation</subject><subject>Immunostimulatory activity</subject><subject>interleukin-10</subject><subject>Interleukin-10 - metabolism</subject><subject>Lymphocyte Subsets</subject><subject>macrophages</subject><subject>Medical sciences</subject><subject>messenger RNA</subject><subject>Mice</subject><subject>natural killer cells</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Oriental traditional medicine</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Proteins - pharmacology</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharide–protein complex</subject><subject>sarcoma</subject><subject>Scolopendra</subject><subject>Scolopendra subspinipes mutilans L. Koch</subject><subject>Toxicology</subject><subject>transforming growth factor beta</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhiMEokPhAdiAN0hsEmwnsROxqipuYiQWpWvLOTluPYrjYDtVZ8czwBvyJLjMADtYefP9F5-_KJ4yWjHKxKtdZSBVnDJe0bairLtXbFgn61LULbtfbCiXXSl61p4Uj2LcUUolk-JhccK5YDVnclN8O5uTTavzgeh5JNa5dfYxWbdOOvmwJxqSvbFpT7whmix-2kcNcK2DHfHH1-9L8AntTMC7ZcJbYoJ35AL85Becx6BJXIe42NkuGIlbk530HMm2Ih89XJMs_JVdDpgN5yviLODj4oHRU8Qnx_e0uHz75vP5-3L76d2H87NtCU1DU8kRAEFwSrVmrUHadnww3QjA6q7FoWZDp3s-QMPlILGjNYdGa0rH3owo2_q0eHnwzX_4smJMytkIOOWG6NeomJCibkQn-P_RfGkh-5yUUXZAIfgYAxq1BOt02GdI3a2mdiqvpu5WU7RVebWseXa0XweH4x_F75ky8OII6Ah6MkHPYONfLl9B9p3I3PMDZ7RX-ipk5vIiJ7WUMslpTzPx-kBgvuyNxaAiWJwBRxsw1xq9_UfRnxWxwqo</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Zhao, Haixia</creator><creator>Li, Ying</creator><creator>Wang, Yuzhong</creator><creator>Zhang, Jing</creator><creator>Ouyang, Xiaoming</creator><creator>Peng, Renxiu</creator><creator>Yang, Jing</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20120801</creationdate><title>Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice</title><author>Zhao, Haixia ; Li, Ying ; Wang, Yuzhong ; Zhang, Jing ; Ouyang, Xiaoming ; Peng, Renxiu ; Yang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-2eccec6200aa15fe0582bf8dcc1385eb31b8a92bc427b7e8032c4aa00d9fde753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Antitumor</topic><topic>arachidonic acid</topic><topic>Biological and medical sciences</topic><topic>Catalysis</topic><topic>CD4-positive T-lymphocytes</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>cytotoxic T-lymphocytes</topic><topic>Diterpene Alkaloids</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>enzymes</topic><topic>gene expression</topic><topic>hepatoma</topic><topic>immune response</topic><topic>immunomodulation</topic><topic>Immunostimulatory activity</topic><topic>interleukin-10</topic><topic>Interleukin-10 - metabolism</topic><topic>Lymphocyte Subsets</topic><topic>macrophages</topic><topic>Medical sciences</topic><topic>messenger RNA</topic><topic>Mice</topic><topic>natural killer cells</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Oriental traditional medicine</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Proteins - pharmacology</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharide–protein complex</topic><topic>sarcoma</topic><topic>Scolopendra</topic><topic>Scolopendra subspinipes mutilans L. Koch</topic><topic>Toxicology</topic><topic>transforming growth factor beta</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Haixia</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Wang, Yuzhong</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Ouyang, Xiaoming</creatorcontrib><creatorcontrib>Peng, Renxiu</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Haixia</au><au>Li, Ying</au><au>Wang, Yuzhong</au><au>Zhang, Jing</au><au>Ouyang, Xiaoming</au><au>Peng, Renxiu</au><au>Yang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>50</volume><issue>8</issue><spage>2648</spage><epage>2655</epage><pages>2648-2655</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>► A novel polysaccharide–protein complex from Scolopendra subspinipes mutilans (SPPC). ► SPPC suppressed the growth of sarcoma S180 and hepatoma H22 in vivo. ► SPPC remarkably enhanced antitumor immune responses in S180-bearing mice. ► SPPC inhibited arachidonic acid-metabolic pathways in tumor-associated macrophages. ► SPPC could act as an anti-tumor agent with immunomodulatory activity.
Scolopendra subspinipes mutilans L. Koch has been used for cancer treatment in traditional Chinese medicine for hundreds of years. In this study, the effects of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch (SPPC) on the tumor growth and immune function were assessed in sarcoma S180 and hepatoma H22 bearing mice. Results showed that SPPC significantly inhibited the growth of S180 transplanted in mice and prolonged the survival time of H22- bearing mice. In S180-bearing mice, it promoted specific and nonspecific immune response as evidenced by enhancing the activities of natural killer (NK) cells, cytotoxic T lymphocytes (CTL) and the ratio of Th1/Th2 cytokines, and increasing the percentages of CD4+ T cells, B cells and NK cells. Furthermore, SPPC not only significantly inhibited mRNA expression and production of the immunosuppressive cytokines (IL-10 and TGF-β), but also diminished arachidonic acid (AA)-metabolizing enzymes (COX-2 and CYP4A) and their products (PGE2 and 20-HETE) in tumor-associated macrophages (TAMs). Taken together, our results indicate that SPPC inhibits tumor growth in vivo by improving antitumor immune responses at least partly via downregulating AA-metabolic pathways in TAMs, and could act as an anti-tumor agent with immunomodulatory activity.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>22613217</pmid><doi>10.1016/j.fct.2012.05.018</doi><tpages>8</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - pharmacology Animals antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Antitumor arachidonic acid Biological and medical sciences Catalysis CD4-positive T-lymphocytes Cell Line, Tumor Cell Proliferation - drug effects cytotoxic T-lymphocytes Diterpene Alkaloids Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry enzymes gene expression hepatoma immune response immunomodulation Immunostimulatory activity interleukin-10 Interleukin-10 - metabolism Lymphocyte Subsets macrophages Medical sciences messenger RNA Mice natural killer cells Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Oriental traditional medicine Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Proteins - pharmacology Polysaccharides - pharmacology Polysaccharide–protein complex sarcoma Scolopendra Scolopendra subspinipes mutilans L. Koch Toxicology transforming growth factor beta Transforming Growth Factor beta - metabolism |
| title | Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice |
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