Topical application of Pleurotus eryngii extracts inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance

► Effect of Pleurotus eryngii extracts (PEE) on AD-like skin lesions was assayed. ► PEE suppressed dermatitis severity and serum levels of IgE and TARC. ► PEE suppressed mRNA expression of IL-4, IL-5, IL-13, TNF-α, and INF-γ. ► PEE reduced thickness of dermis in ear lesions. ► PEE inhibited infiltra...

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Veröffentlicht in:	Food and chemical toxicology 2013-03, Vol.53, p.38-45
Hauptverfasser:	Choi, Jae Ho, Kim, Hyung Gyun, Jin, Sun Woo, Han, Eun Hee, Khanal, Tilak, Do, Minh Truong, Hwang, Yong Pil, Choi, Jun Min, Chun, Sung-Sik, Chung, Young Chul, Jeong, Tae Cheon, Jeong, Hye Gwang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Animals Atopic dermatitis Biological and medical sciences blood serum CD4-positive T-lymphocytes chemokine CCL17 Chemokine CCL17 - blood contact dermatitis Dermatitis, Atopic - chemically induced Dermatitis, Atopic - drug therapy Dermatitis, Atopic - pathology dermis Dinitrochlorobenzene - adverse effects ears functional foods gene expression histopathology IgE immunoglobulin E Immunoglobulin E - blood Immunopathology interferon-gamma Interferon-gamma - genetics Interferon-gamma - metabolism interleukin-13 Interleukin-13 - genetics Interleukin-13 - metabolism interleukin-4 Interleukin-4 - genetics Interleukin-4 - metabolism interleukin-5 Interleukin-5 - genetics Interleukin-5 - metabolism Male mast cells Mast Cells - drug effects Mast Cells - metabolism Medical sciences messenger RNA Mice NC/Nga mice Pleurotus Pleurotus eryngii polysaccharides Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Skin allergic diseases. Stinging insect allergies skin lesions TARC Th1-Th2 Balance - drug effects topical application Toxicology tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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