The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice

► We examine protection of Se pretreatment on Cd toxicity at three time points. ► Protection of Se on spermatogenesis is corroborated by FCM. ► Se ameliorates testosterone decrease induced by Cd. ► Se can activate StAR and testosterone synthetic enzymes activity. Selenium (Se) is an essential trance...

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Veröffentlicht in:	Food and chemical toxicology 2012-10, Vol.50 (10), p.3521-3529
Hauptverfasser:	Ren, Xiang-mei, Wang, Gai-gai, Xu, Dong-qing, Luo, Kang, Liu, Yu-xin, Zhong, Yi-hong, Cai, Yun-qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Biological and medical sciences Body Weight - drug effects Cadmium Cadmium - toxicity Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Environmental Pollutants - toxicity Gene Expression Regulation Glutathione Peroxidase - metabolism Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Medical sciences Metals and various inorganic compounds Mice Mice, Inbred ICR Organ Size Selenium Selenium - administration & dosage Selenium - pharmacology Sperm Motility - drug effects Sperm Motility - physiology Sperm parameters Spermatogenesis Spermatogenesis - drug effects Spermatozoa - drug effects Spermatozoa - physiology Superoxide Dismutase - metabolism Testes Testis - drug effects Testis - pathology Testis - physiology Testosterone Testosterone - biosynthesis Toxicology
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