Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells

•Fifteen phenolic compounds were isolated from Chamaecyparis obtusa.•3, 4 and 9 showed protective effects in glutamate-injured HT22 cells.•The reduced activities of antioxidant enzymes induced by glutamate were preserved by 3, 4 or 9.•The reduced content of GSH, and the increased production of ROS b...

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