Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

Understanding how compound penetration occurs across the complex cell walls of Gram-negative bacteria is one of the greatest challenges in discovering new drugs to treat the infections they cause. A combination of next-generation transposon sequencing, computational metadynamics simulations (CMDS),...

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Veröffentlicht in:	Chemistry & biology 2015-04, Vol.22 (4), p.535-547
Hauptverfasser:	Isabella, Vincent M., Campbell, Arthur J., Manchester, John, Sylvester, Mark, Nayar, Asha S., Ferguson, Keith E., Tommasi, Ruben, Miller, Alita A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Binding Sites Carbapenems - chemistry Carbapenems - metabolism Carbapenems - pharmacology Microbial Sensitivity Tests Molecular Docking Simulation Protein Structure, Tertiary Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Substrate Specificity
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