Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes

Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes and its use as a substrate for glycolysis and mitochondrial oxidation in order to maintain the high cardiac energy demands. Insulin stimulates...

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Veröffentlicht in:	Cell communication and signaling 2014-11, Vol.12, p.68-68
Hauptverfasser:	Gutiérrez, Tomás, Parra, Valentina, Troncoso, Rodrigo, Pennanen, Christian, Contreras-Ferrat, Ariel, Vasquez-Trincado, César, Morales, Pablo E, Lopez-Crisosto, Camila, Sotomayor-Flores, Cristian, Chiong, Mario, Rothermel, Beverly A, Lavandero, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Calcium - metabolism Calcium Signaling Cardiomegaly - metabolism Endoplasmic Reticulum - metabolism Glucose - metabolism Inositol 1,4,5-Trisphosphate Receptors - metabolism Insulin - metabolism Mitochondria, Heart - metabolism Myocytes, Cardiac - metabolism Oxygen Consumption Rats, Sprague-Dawley Signal Transduction
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