Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities

Transcriptional regulation of the human alpha-like globin genes, embryonic zeta 2 and adult alpha, during erythroid development is mediated by a distal enhancer, HS-40. Previous protein-DNA binding studies have shown that HS-40 consists of multiple nuclear factor binding motifs that are occupied in...

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Veröffentlicht in:	The Journal of biological chemistry 1995-04, Vol.270 (15), p.8501-8505
Hauptverfasser:	Zhang, Q, Rombel, I, Reddy, G N, Gang, J B, Shen, C K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Base Sequence Cell Line DNA - physiology Enhancer Elements, Genetic Erythrocytes - physiology Globins - genetics Humans Molecular Sequence Data Mutagenesis, Site-Directed Oligodeoxyribonucleotides Transcription Factors - metabolism
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