Impaired mucosal immune responses in interleukin 4-targeted mice

Interleukin 4-targeted (IL-4-/-) mice are defective in T helper (Th)2 cytokine production as determined after nematode infection. As Th2 cells appear to be selectively induced by oral immunization we investigated the ability of IL-4-/- mice to respond to perorally administered antigen. We found that...

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Veröffentlicht in:	The Journal of experimental medicine 1995-01, Vol.181 (1), p.41-53
Hauptverfasser:	Vajdy, M, Kosco-Vilbois, M H, Kopf, M, Köhler, G, Lycke, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Administration, Oral Animals Antibody-Producing Cells - cytology Antibody-Producing Cells - immunology Antigens - administration & dosage Antigens - chemistry Cholera Toxin - immunology Hemocyanins - immunology Immunoglobulin A - metabolism Interleukin-4 - physiology Intestinal Mucosa - cytology Intestinal Mucosa - immunology Lymph Nodes - cytology Lymph Nodes - immunology Mesentery Mice Mice, Knockout Ovalbumin - immunology Peyer's Patches - immunology Solubility Th2 Cells - immunology
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