Warfarin therapy and perioperative transfusion requirement with bleeding amount in patients undergoing cardiac surgery with cardiopulmonary bypass: a retrospective study
SUMMARY Objectives The study was designed to evaluate the effect of warfarin on perioperative transfusion, bleeding and coagulation status in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Background There were controversy about the effect of warfarin on perioperative transfu...
Gespeichert in:
| Veröffentlicht in: | Transfusion medicine (Oxford, England) England), 2015-02, Vol.25 (1), p.33-37 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 37 |
|---|---|
| container_issue | 1 |
| container_start_page | 33 |
| container_title | Transfusion medicine (Oxford, England) |
| container_volume | 25 |
| creator | Oh, C.-S. Choi, J.-W. Jung, E. Kang, W.-S. Kim, S.-H. |
| description | SUMMARY
Objectives
The study was designed to evaluate the effect of warfarin on perioperative transfusion, bleeding and coagulation status in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
Background
There were controversy about the effect of warfarin on perioperative transfusion and bleeding.
Methods/Materials
Medical records from 107 consecutive patients with atrial fibrillation (AF) on warfarin therapy undergoing cardiac surgery with cardiopulmonary bypass (CPB) from 2008 to 2013 at a single university teaching hospital were retrospectively reviewed to compare the patients on to those not on warfarin therapy in terms of perioperative transfusion requirement, postoperative 24‐h bleeding amount, and coagulation status assessment using prothrombin time (PT), international normalised ratio (INR) and rotational thromboelastometry (ROTEM®).
Results
Although PT/INR was significantly prolonged both before and after surgery in patients on warfarin therapy, ROTEM® data, perioperative transfusion requirement and postoperative 24‐h bleeding amount (785 ± 331 vs 676 ± 303 mL, P = 0·089, respectively) were not significantly different between the patients on and those not on warfarin therapy.
Conclusion
In patients on warfarin therapy undergoing cardiac surgery with CPB, warfarin therapy did not significantly increase perioperative transfusion requirement and bleeding. |
| doi_str_mv | 10.1111/tme.12175 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1675876897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1675876897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4335-3e5b3bf983fcc30c742e684af390ea836ae5a953e1c69afa95d1320cfe1721543</originalsourceid><addsrcrecordid>eNp1UctO3DAUtapWZaBd9AcqL8siEMdx4nRXjRiKBGUDmu6sG-dmcJsXfpTmk_jLmgmwqxe2de85x_f4EPKJpScsrlPf4wnLWCnekBXjhUg4y-VbskorIZNSlPKAHDr3K00Zz6rsPTnIRCF5kfEVedyCbcGagfo7tDDNFIaGTmjNGDfw5g9Sb2FwbXBmHKjF-2As9jh4-mD8Ha07xMYMOwr9GGIxKk2RFvuOhqFBuxufuhpsY0BTF-wO7bxw98VxCl0_DhCL9TyBc18pxGe8Hd2Eej-A86GZP5B3LXQOPz6fR-R2c3az_p5cXp9frL9dJjrnPFpHUfO6rSRvteapLvMMC5lDy6sUIboGFFAJjkwXFbTx2sRfSXWLrMyYyPkR-bLoTna8D-i86o3T2HUw4BicYkUpZFnIqozQ4wWq47DOYqsma_roRLFUPSWjYjJqn0zEfn6WDXWPzSvyJYoIOF0AD6bD-f9K6ubq7EUyWRjGefz7ygD7WxUlj8jtj3P1cyvldrPeKMn_AfVYrVY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1675876897</pqid></control><display><type>article</type><title>Warfarin therapy and perioperative transfusion requirement with bleeding amount in patients undergoing cardiac surgery with cardiopulmonary bypass: a retrospective study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Oh, C.-S. ; Choi, J.-W. ; Jung, E. ; Kang, W.-S. ; Kim, S.-H.</creator><creatorcontrib>Oh, C.-S. ; Choi, J.-W. ; Jung, E. ; Kang, W.-S. ; Kim, S.-H.</creatorcontrib><description>SUMMARY
Objectives
The study was designed to evaluate the effect of warfarin on perioperative transfusion, bleeding and coagulation status in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
Background
There were controversy about the effect of warfarin on perioperative transfusion and bleeding.
Methods/Materials
Medical records from 107 consecutive patients with atrial fibrillation (AF) on warfarin therapy undergoing cardiac surgery with cardiopulmonary bypass (CPB) from 2008 to 2013 at a single university teaching hospital were retrospectively reviewed to compare the patients on to those not on warfarin therapy in terms of perioperative transfusion requirement, postoperative 24‐h bleeding amount, and coagulation status assessment using prothrombin time (PT), international normalised ratio (INR) and rotational thromboelastometry (ROTEM®).
Results
Although PT/INR was significantly prolonged both before and after surgery in patients on warfarin therapy, ROTEM® data, perioperative transfusion requirement and postoperative 24‐h bleeding amount (785 ± 331 vs 676 ± 303 mL, P = 0·089, respectively) were not significantly different between the patients on and those not on warfarin therapy.
Conclusion
In patients on warfarin therapy undergoing cardiac surgery with CPB, warfarin therapy did not significantly increase perioperative transfusion requirement and bleeding.</description><identifier>ISSN: 0958-7578</identifier><identifier>EISSN: 1365-3148</identifier><identifier>DOI: 10.1111/tme.12175</identifier><identifier>PMID: 25683623</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Anticoagulants - administration & dosage ; Blood Loss, Surgical ; Blood Transfusion ; cardiac surgery ; Cardiopulmonary Bypass ; Female ; Humans ; international normalised ratio ; Male ; Middle Aged ; Perioperative Care ; Retrospective Studies ; thromboelastometry ; warfarin ; Warfarin - administration & dosage</subject><ispartof>Transfusion medicine (Oxford, England), 2015-02, Vol.25 (1), p.33-37</ispartof><rights>2015 British Blood Transfusion Society</rights><rights>2015 British Blood Transfusion Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4335-3e5b3bf983fcc30c742e684af390ea836ae5a953e1c69afa95d1320cfe1721543</citedby><cites>FETCH-LOGICAL-c4335-3e5b3bf983fcc30c742e684af390ea836ae5a953e1c69afa95d1320cfe1721543</cites><orcidid>0000-0001-7764-9818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftme.12175$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftme.12175$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25683623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, C.-S.</creatorcontrib><creatorcontrib>Choi, J.-W.</creatorcontrib><creatorcontrib>Jung, E.</creatorcontrib><creatorcontrib>Kang, W.-S.</creatorcontrib><creatorcontrib>Kim, S.-H.</creatorcontrib><title>Warfarin therapy and perioperative transfusion requirement with bleeding amount in patients undergoing cardiac surgery with cardiopulmonary bypass: a retrospective study</title><title>Transfusion medicine (Oxford, England)</title><addtitle>Transfusion Med</addtitle><description>SUMMARY
Objectives
The study was designed to evaluate the effect of warfarin on perioperative transfusion, bleeding and coagulation status in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
Background
There were controversy about the effect of warfarin on perioperative transfusion and bleeding.
Methods/Materials
Medical records from 107 consecutive patients with atrial fibrillation (AF) on warfarin therapy undergoing cardiac surgery with cardiopulmonary bypass (CPB) from 2008 to 2013 at a single university teaching hospital were retrospectively reviewed to compare the patients on to those not on warfarin therapy in terms of perioperative transfusion requirement, postoperative 24‐h bleeding amount, and coagulation status assessment using prothrombin time (PT), international normalised ratio (INR) and rotational thromboelastometry (ROTEM®).
Results
Although PT/INR was significantly prolonged both before and after surgery in patients on warfarin therapy, ROTEM® data, perioperative transfusion requirement and postoperative 24‐h bleeding amount (785 ± 331 vs 676 ± 303 mL, P = 0·089, respectively) were not significantly different between the patients on and those not on warfarin therapy.
Conclusion
In patients on warfarin therapy undergoing cardiac surgery with CPB, warfarin therapy did not significantly increase perioperative transfusion requirement and bleeding.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticoagulants - administration & dosage</subject><subject>Blood Loss, Surgical</subject><subject>Blood Transfusion</subject><subject>cardiac surgery</subject><subject>Cardiopulmonary Bypass</subject><subject>Female</subject><subject>Humans</subject><subject>international normalised ratio</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Perioperative Care</subject><subject>Retrospective Studies</subject><subject>thromboelastometry</subject><subject>warfarin</subject><subject>Warfarin - administration & dosage</subject><issn>0958-7578</issn><issn>1365-3148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctO3DAUtapWZaBd9AcqL8siEMdx4nRXjRiKBGUDmu6sG-dmcJsXfpTmk_jLmgmwqxe2de85x_f4EPKJpScsrlPf4wnLWCnekBXjhUg4y-VbskorIZNSlPKAHDr3K00Zz6rsPTnIRCF5kfEVedyCbcGagfo7tDDNFIaGTmjNGDfw5g9Sb2FwbXBmHKjF-2As9jh4-mD8Ha07xMYMOwr9GGIxKk2RFvuOhqFBuxufuhpsY0BTF-wO7bxw98VxCl0_DhCL9TyBc18pxGe8Hd2Eej-A86GZP5B3LXQOPz6fR-R2c3az_p5cXp9frL9dJjrnPFpHUfO6rSRvteapLvMMC5lDy6sUIboGFFAJjkwXFbTx2sRfSXWLrMyYyPkR-bLoTna8D-i86o3T2HUw4BicYkUpZFnIqozQ4wWq47DOYqsma_roRLFUPSWjYjJqn0zEfn6WDXWPzSvyJYoIOF0AD6bD-f9K6ubq7EUyWRjGefz7ygD7WxUlj8jtj3P1cyvldrPeKMn_AfVYrVY</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Oh, C.-S.</creator><creator>Choi, J.-W.</creator><creator>Jung, E.</creator><creator>Kang, W.-S.</creator><creator>Kim, S.-H.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7764-9818</orcidid></search><sort><creationdate>201502</creationdate><title>Warfarin therapy and perioperative transfusion requirement with bleeding amount in patients undergoing cardiac surgery with cardiopulmonary bypass: a retrospective study</title><author>Oh, C.-S. ; Choi, J.-W. ; Jung, E. ; Kang, W.-S. ; Kim, S.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4335-3e5b3bf983fcc30c742e684af390ea836ae5a953e1c69afa95d1320cfe1721543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anticoagulants - administration & dosage</topic><topic>Blood Loss, Surgical</topic><topic>Blood Transfusion</topic><topic>cardiac surgery</topic><topic>Cardiopulmonary Bypass</topic><topic>Female</topic><topic>Humans</topic><topic>international normalised ratio</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Perioperative Care</topic><topic>Retrospective Studies</topic><topic>thromboelastometry</topic><topic>warfarin</topic><topic>Warfarin - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, C.-S.</creatorcontrib><creatorcontrib>Choi, J.-W.</creatorcontrib><creatorcontrib>Jung, E.</creatorcontrib><creatorcontrib>Kang, W.-S.</creatorcontrib><creatorcontrib>Kim, S.-H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion medicine (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, C.-S.</au><au>Choi, J.-W.</au><au>Jung, E.</au><au>Kang, W.-S.</au><au>Kim, S.-H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Warfarin therapy and perioperative transfusion requirement with bleeding amount in patients undergoing cardiac surgery with cardiopulmonary bypass: a retrospective study</atitle><jtitle>Transfusion medicine (Oxford, England)</jtitle><addtitle>Transfusion Med</addtitle><date>2015-02</date><risdate>2015</risdate><volume>25</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>0958-7578</issn><eissn>1365-3148</eissn><abstract>SUMMARY
Objectives
The study was designed to evaluate the effect of warfarin on perioperative transfusion, bleeding and coagulation status in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
Background
There were controversy about the effect of warfarin on perioperative transfusion and bleeding.
Methods/Materials
Medical records from 107 consecutive patients with atrial fibrillation (AF) on warfarin therapy undergoing cardiac surgery with cardiopulmonary bypass (CPB) from 2008 to 2013 at a single university teaching hospital were retrospectively reviewed to compare the patients on to those not on warfarin therapy in terms of perioperative transfusion requirement, postoperative 24‐h bleeding amount, and coagulation status assessment using prothrombin time (PT), international normalised ratio (INR) and rotational thromboelastometry (ROTEM®).
Results
Although PT/INR was significantly prolonged both before and after surgery in patients on warfarin therapy, ROTEM® data, perioperative transfusion requirement and postoperative 24‐h bleeding amount (785 ± 331 vs 676 ± 303 mL, P = 0·089, respectively) were not significantly different between the patients on and those not on warfarin therapy.
Conclusion
In patients on warfarin therapy undergoing cardiac surgery with CPB, warfarin therapy did not significantly increase perioperative transfusion requirement and bleeding.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>25683623</pmid><doi>10.1111/tme.12175</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7764-9818</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0958-7578 |
| ispartof | Transfusion medicine (Oxford, England), 2015-02, Vol.25 (1), p.33-37 |
| issn | 0958-7578 1365-3148 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1675876897 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Anticoagulants - administration & dosage Blood Loss, Surgical Blood Transfusion cardiac surgery Cardiopulmonary Bypass Female Humans international normalised ratio Male Middle Aged Perioperative Care Retrospective Studies thromboelastometry warfarin Warfarin - administration & dosage |
| title | Warfarin therapy and perioperative transfusion requirement with bleeding amount in patients undergoing cardiac surgery with cardiopulmonary bypass: a retrospective study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T01%3A17%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Warfarin%20therapy%20and%20perioperative%20transfusion%20requirement%20with%20bleeding%20amount%20in%20patients%20undergoing%20cardiac%20surgery%20with%20cardiopulmonary%20bypass:%20a%20retrospective%20study&rft.jtitle=Transfusion%20medicine%20(Oxford,%20England)&rft.au=Oh,%20C.-S.&rft.date=2015-02&rft.volume=25&rft.issue=1&rft.spage=33&rft.epage=37&rft.pages=33-37&rft.issn=0958-7578&rft.eissn=1365-3148&rft_id=info:doi/10.1111/tme.12175&rft_dat=%3Cproquest_cross%3E1675876897%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1675876897&rft_id=info:pmid/25683623&rfr_iscdi=true |