Experimental Transmission of AA Amyloidosis by Injecting the AA Amyloid Protein Into Interleukin-1 Receptor Antagonist Knockout (IL-1raKO) Mice

The incidence of AA amyloidosis is high in humans with rheumatoid arthritis and several animal species, including cats and cattle with prolonged inflammation. AA amyloidosis can be experimentally induced in mice using severe inflammatory stimuli and a coinjection of AA amyloid; however, difficulties...

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Veröffentlicht in:	Veterinary pathology 2015-05, Vol.52 (3), p.505-512
Hauptverfasser:	Watanabe, K., Uchida, K., Chambers, J. K., Tei, M., Shoji, A., Ushio, N., Nakayama, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidosis - etiology Amyloidosis - pathology Animals Disease Models, Animal Immunoblotting Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - physiology Intestines - pathology Kidney - pathology Liver - pathology Mice, Inbred BALB C Mice, Knockout Myocardium - pathology Serum Amyloid A Protein - analysis Serum Amyloid A Protein - pharmacology Spleen - pathology Thyroid Gland - pathology
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