Does phase 1 trial enrollment preclude quality end‐of‐life care? Phase 1 trial enrollment and end‐of‐life care characteristics in children with cancer

BACKGROUND End‐of‐life care (EOLC) discussions and treatment‐related decisions, including phase 1 trial enrollment, in patients with incurable disease are complex and can influence the quality of EOLC received. The current study was conducted in pediatric oncology patients to determine whether end‐o...

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Veröffentlicht in:	Cancer 2015-05, Vol.121 (9), p.1508-1512
Hauptverfasser:	Levine, Deena R., Johnson, Liza‐Marie, Mandrell, Belinda N., Yang, Jie, West, Nancy K., Hinds, Pamela S., Baker, Justin N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Agents - therapeutic use Brain Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain tumors Cancer Child Child, Preschool Children Clinical Trials, Phase I as Topic Death Demographics Diagnosis end‐of‐life care Female Humans Male Malignancy Medical records Mortality Oncology Patient Selection Patients pediatric oncology Pediatrics phase 1 clinical trials Quality of Health Care Quality of Life Regression analysis Resuscitation Solid tumors Terminal Care - standards Tumors
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Zusammenfassung:	BACKGROUND End‐of‐life care (EOLC) discussions and treatment‐related decisions, including phase 1 trial enrollment, in patients with incurable disease are complex and can influence the quality of EOLC received. The current study was conducted in pediatric oncology patients to determine whether end‐of‐life characteristics differed between those who were and were not enrolled in a phase 1 trial. METHODS The authors reviewed the medical records of 380 pediatric oncology patients (aged
ISSN:	0008-543X 1097-0142
DOI:	10.1002/cncr.29230