Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society
Background Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the...
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| Veröffentlicht in: | Catheterization and cardiovascular interventions 2015-05, Vol.85 (6), p.944-951 |
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| creator | Kwok, Chun Shing Anderson, Simon G. McAllister, Katherine S.L. Sperrin, Matthew O'Kane, Peter D. Keavney, Bernard Nolan, James Myint, Phyo Kyaw Zaman, Azfar Buchan, Iain Ludman, Peter F. de Belder, Mark A. Mamas, Mamas A. |
| description | Background
Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.
Methods
The relationship between LV function and 30‐day mortality in patients undergoing PCI in different age groups ( |
| doi_str_mv | 10.1002/ccd.25732 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1675874059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1675874059</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3172-b4b726796421f87fb275e1bf4a1668dc50ac72031ae9a4d0fccc215669f995923</originalsourceid><addsrcrecordid>eNpdkstu1DAUhiMEohdY8ALIEhs2aW0ntmN2NNB2RMVFAoHYWI7jzLg49mA7U-YxeSOcmaFCrM6Rzv_9OreieIbgGYIQnyvVn2HCKvygOEYE45Jh-u3hIUe8pkfFSYy3EEJOMX9cHGFSw6aCzXHxezGupUrAD0AuNfAOpJUG6-CXzsdkFNhIO-m5bPWQwEa7FIyarAxgmJxKJhPGgaCt3OXJz7DS_RSkBX5Kyo86gsFb6--MW4K1DmpK0mk_RaB88E6GbbZIOszm2eMVWLholquUseDHXUMXwSQTV0DJ0Bu_kXHfwr8YiF4ZnbZPikeDtFE_PcTT4svl28_tdXnz4WrRvr4pTYUYLru6y1tinNYYDQ0bOsyIRt1QS0Rp0ysCpWIYVkhqLuseDkopjAilfOCccFydFi_3vnnen5OOSYwmKm3tfjaBKCMNqyHhWfriP-mtn4LL3c2qmsMq3yirnh9UUzfqXqyDGfNuxN9jZcH5XnBnrN7e1xEU8xeI_AVi9wWibd_skkyUe8LEpH_dEzL8EJRVjIiv76_Ex-_0uuUX78Sn6g858Llj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1674903946</pqid></control><display><type>article</type><title>Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Kwok, Chun Shing ; Anderson, Simon G. ; McAllister, Katherine S.L. ; Sperrin, Matthew ; O'Kane, Peter D. ; Keavney, Bernard ; Nolan, James ; Myint, Phyo Kyaw ; Zaman, Azfar ; Buchan, Iain ; Ludman, Peter F. ; de Belder, Mark A. ; Mamas, Mamas A.</creator><creatorcontrib>Kwok, Chun Shing ; Anderson, Simon G. ; McAllister, Katherine S.L. ; Sperrin, Matthew ; O'Kane, Peter D. ; Keavney, Bernard ; Nolan, James ; Myint, Phyo Kyaw ; Zaman, Azfar ; Buchan, Iain ; Ludman, Peter F. ; de Belder, Mark A. ; Mamas, Mamas A. ; British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research</creatorcontrib><description><![CDATA[Background
Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.
Methods
The relationship between LV function and 30‐day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.
Results
Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30‐day mortality outcomes in all age groups (OR 5.65:95% CI 4.21–7.58, age <60 years; OR 5.07: 95% CI 3.91–6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64–5.57, 70 to <80 years and OR 4.83:95% CI 3.79–6.15, age ≥80 years).
Conclusions
Our analysis suggests that worsening LV function is an important independent predictor of worse 30‐day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.]]></description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.25732</identifier><identifier>PMID: 25408308</identifier><identifier>CODEN: CARIF2</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>age ; Age Factors ; Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - methods ; Cardiology ; Cohort Studies ; Coronary Angiography - methods ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Coronary Artery Disease - therapy ; Coronary vessels ; Female ; Heart attacks ; Hospital Mortality - trends ; Humans ; left ventricular function ; Male ; Middle Aged ; Mortality ; Odds Ratio ; PCI ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - methods ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Societies, Medical ; Society ; Survival Analysis ; Treatment Outcome ; United Kingdom ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - mortality ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left - physiology</subject><ispartof>Catheterization and cardiovascular interventions, 2015-05, Vol.85 (6), p.944-951</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.25732$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.25732$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25408308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwok, Chun Shing</creatorcontrib><creatorcontrib>Anderson, Simon G.</creatorcontrib><creatorcontrib>McAllister, Katherine S.L.</creatorcontrib><creatorcontrib>Sperrin, Matthew</creatorcontrib><creatorcontrib>O'Kane, Peter D.</creatorcontrib><creatorcontrib>Keavney, Bernard</creatorcontrib><creatorcontrib>Nolan, James</creatorcontrib><creatorcontrib>Myint, Phyo Kyaw</creatorcontrib><creatorcontrib>Zaman, Azfar</creatorcontrib><creatorcontrib>Buchan, Iain</creatorcontrib><creatorcontrib>Ludman, Peter F.</creatorcontrib><creatorcontrib>de Belder, Mark A.</creatorcontrib><creatorcontrib>Mamas, Mamas A.</creatorcontrib><creatorcontrib>British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research</creatorcontrib><title>Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society</title><title>Catheterization and cardiovascular interventions</title><addtitle>Cathet. Cardiovasc. Intervent</addtitle><description><![CDATA[Background
Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.
Methods
The relationship between LV function and 30‐day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.
Results
Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30‐day mortality outcomes in all age groups (OR 5.65:95% CI 4.21–7.58, age <60 years; OR 5.07: 95% CI 3.91–6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64–5.57, 70 to <80 years and OR 4.83:95% CI 3.79–6.15, age ≥80 years).
Conclusions
Our analysis suggests that worsening LV function is an important independent predictor of worse 30‐day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.]]></description><subject>age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Cardiology</subject><subject>Cohort Studies</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>left ventricular function</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Odds Ratio</subject><subject>PCI</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - methods</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Societies, Medical</subject><subject>Society</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>United Kingdom</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - mortality</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left - physiology</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkstu1DAUhiMEohdY8ALIEhs2aW0ntmN2NNB2RMVFAoHYWI7jzLg49mA7U-YxeSOcmaFCrM6Rzv_9OreieIbgGYIQnyvVn2HCKvygOEYE45Jh-u3hIUe8pkfFSYy3EEJOMX9cHGFSw6aCzXHxezGupUrAD0AuNfAOpJUG6-CXzsdkFNhIO-m5bPWQwEa7FIyarAxgmJxKJhPGgaCt3OXJz7DS_RSkBX5Kyo86gsFb6--MW4K1DmpK0mk_RaB88E6GbbZIOszm2eMVWLholquUseDHXUMXwSQTV0DJ0Bu_kXHfwr8YiF4ZnbZPikeDtFE_PcTT4svl28_tdXnz4WrRvr4pTYUYLru6y1tinNYYDQ0bOsyIRt1QS0Rp0ysCpWIYVkhqLuseDkopjAilfOCccFydFi_3vnnen5OOSYwmKm3tfjaBKCMNqyHhWfriP-mtn4LL3c2qmsMq3yirnh9UUzfqXqyDGfNuxN9jZcH5XnBnrN7e1xEU8xeI_AVi9wWibd_skkyUe8LEpH_dEzL8EJRVjIiv76_Ex-_0uuUX78Sn6g858Llj</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Kwok, Chun Shing</creator><creator>Anderson, Simon G.</creator><creator>McAllister, Katherine S.L.</creator><creator>Sperrin, Matthew</creator><creator>O'Kane, Peter D.</creator><creator>Keavney, Bernard</creator><creator>Nolan, James</creator><creator>Myint, Phyo Kyaw</creator><creator>Zaman, Azfar</creator><creator>Buchan, Iain</creator><creator>Ludman, Peter F.</creator><creator>de Belder, Mark A.</creator><creator>Mamas, Mamas A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society</title><author>Kwok, Chun Shing ; Anderson, Simon G. ; McAllister, Katherine S.L. ; Sperrin, Matthew ; O'Kane, Peter D. ; Keavney, Bernard ; Nolan, James ; Myint, Phyo Kyaw ; Zaman, Azfar ; Buchan, Iain ; Ludman, Peter F. ; de Belder, Mark A. ; Mamas, Mamas A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3172-b4b726796421f87fb275e1bf4a1668dc50ac72031ae9a4d0fccc215669f995923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Cardiology</topic><topic>Cohort Studies</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>left ventricular function</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Odds Ratio</topic><topic>PCI</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - methods</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Societies, Medical</topic><topic>Society</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>United Kingdom</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - mortality</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwok, Chun Shing</creatorcontrib><creatorcontrib>Anderson, Simon G.</creatorcontrib><creatorcontrib>McAllister, Katherine S.L.</creatorcontrib><creatorcontrib>Sperrin, Matthew</creatorcontrib><creatorcontrib>O'Kane, Peter D.</creatorcontrib><creatorcontrib>Keavney, Bernard</creatorcontrib><creatorcontrib>Nolan, James</creatorcontrib><creatorcontrib>Myint, Phyo Kyaw</creatorcontrib><creatorcontrib>Zaman, Azfar</creatorcontrib><creatorcontrib>Buchan, Iain</creatorcontrib><creatorcontrib>Ludman, Peter F.</creatorcontrib><creatorcontrib>de Belder, Mark A.</creatorcontrib><creatorcontrib>Mamas, Mamas A.</creatorcontrib><creatorcontrib>British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwok, Chun Shing</au><au>Anderson, Simon G.</au><au>McAllister, Katherine S.L.</au><au>Sperrin, Matthew</au><au>O'Kane, Peter D.</au><au>Keavney, Bernard</au><au>Nolan, James</au><au>Myint, Phyo Kyaw</au><au>Zaman, Azfar</au><au>Buchan, Iain</au><au>Ludman, Peter F.</au><au>de Belder, Mark A.</au><au>Mamas, Mamas A.</au><aucorp>British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Cathet. Cardiovasc. Intervent</addtitle><date>2015-05</date><risdate>2015</risdate><volume>85</volume><issue>6</issue><spage>944</spage><epage>951</epage><pages>944-951</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><coden>CARIF2</coden><abstract><![CDATA[Background
Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.
Methods
The relationship between LV function and 30‐day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.
Results
Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30‐day mortality outcomes in all age groups (OR 5.65:95% CI 4.21–7.58, age <60 years; OR 5.07: 95% CI 3.91–6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64–5.57, 70 to <80 years and OR 4.83:95% CI 3.79–6.15, age ≥80 years).
Conclusions
Our analysis suggests that worsening LV function is an important independent predictor of worse 30‐day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.]]></abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25408308</pmid><doi>10.1002/ccd.25732</doi><tpages>8</tpages></addata></record> |
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| subjects | age Age Factors Aged Aged, 80 and over Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - methods Cardiology Cohort Studies Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Coronary Artery Disease - therapy Coronary vessels Female Heart attacks Hospital Mortality - trends Humans left ventricular function Male Middle Aged Mortality Odds Ratio PCI Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - methods Predictive Value of Tests Prognosis Retrospective Studies Risk Assessment Severity of Illness Index Societies, Medical Society Survival Analysis Treatment Outcome United Kingdom Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - mortality Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology |
| title | Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society |
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