A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease
Summary Background & aims Secondary prevention can improve outcomes in high risk patients. This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. Design 30 patients with type II diabetes...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2015-06, Vol.34 (3), p.541-548 |
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| container_title | Clinical nutrition (Edinburgh, Scotland) |
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| creator | Keith, Mary Kuliszewski, Michael A Liao, Christine Peeva, Valentina Ahmed, Mavra Tran, Susan Sorokin, Kevin Jenkins, David J Errett, Lee Leong-Poi, Howard |
| description | Summary Background & aims Secondary prevention can improve outcomes in high risk patients. This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. Design 30 patients with type II diabetes, 6 weeks post bypass surgery received dietary counseling on a Modified Portfolio Diet (MPD) (low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein and 22 g/1000 kcal almonds). Lipid profiles, endothelial function and markers of glycemic control, oxidative stress and inflammation were measured at baseline and following two and four weeks of intervention. Seven patients with no diet therapy served as time controls. Results Consumption of the MPD resulted in a 19% relative reduction in LDL (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L, p |
| doi_str_mv | 10.1016/j.clnu.2014.06.010 |
| format | Article |
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This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. Design 30 patients with type II diabetes, 6 weeks post bypass surgery received dietary counseling on a Modified Portfolio Diet (MPD) (low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein and 22 g/1000 kcal almonds). Lipid profiles, endothelial function and markers of glycemic control, oxidative stress and inflammation were measured at baseline and following two and four weeks of intervention. Seven patients with no diet therapy served as time controls. Results Consumption of the MPD resulted in a 19% relative reduction in LDL (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L, p < 0.001) with no change in HDL cholesterol. Homocysteine levels dropped significantly (10.1 ± 2.7 vs 7.9 ± 4 μmol/L, p = 0.006) over the study period. Flow mediated dilatation increased significantly in treated patients (3.8 ± 3.8% to 6.5 ± 3.6%, p = 0.004) while remaining constant in controls ( p = 0.6). Endothelial progenitor cells numbers (CD34+, CD 133+ and UEA-1+) increased significantly following MPD consumption ( p < 0.02) with no difference in migratory capacity. In contrast, time controls showed no significant changes. Conclusion Dietary intervention in medically managed, high risk patients resulted in important reductions in risk factors. Clinical Trials registry number NCT00462436.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2014.06.010</identifier><identifier>PMID: 25023926</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Biomarkers - blood ; Blood Glucose - metabolism ; Cardiovascular risk ; Case-Control Studies ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary Artery Disease - complications ; Coronary Artery Disease - diet therapy ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diet therapy ; Diet, Fat-Restricted ; Dietary Fats - administration & dosage ; Dietary Fiber - administration & dosage ; Dietary portfolio ; Endothelial function ; Endothelial progenitor cells ; Energy Intake ; Female ; Gastroenterology and Hepatology ; Homocysteine - blood ; Humans ; LDL cholesterol ; Male ; Middle Aged ; Motor Activity ; Patient Compliance ; Pilot Projects ; Risk Factors ; Soybean Proteins - administration & dosage</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2015-06, Vol.34 (3), p.541-548</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-4072049d029aba0f69c8077686a571e7509446a92403cdad250987bc35aea80c3</citedby><cites>FETCH-LOGICAL-c481t-4072049d029aba0f69c8077686a571e7509446a92403cdad250987bc35aea80c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2014.06.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25023926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keith, Mary</creatorcontrib><creatorcontrib>Kuliszewski, Michael A</creatorcontrib><creatorcontrib>Liao, Christine</creatorcontrib><creatorcontrib>Peeva, Valentina</creatorcontrib><creatorcontrib>Ahmed, Mavra</creatorcontrib><creatorcontrib>Tran, Susan</creatorcontrib><creatorcontrib>Sorokin, Kevin</creatorcontrib><creatorcontrib>Jenkins, David J</creatorcontrib><creatorcontrib>Errett, Lee</creatorcontrib><creatorcontrib>Leong-Poi, Howard</creatorcontrib><title>A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background & aims Secondary prevention can improve outcomes in high risk patients. This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. Design 30 patients with type II diabetes, 6 weeks post bypass surgery received dietary counseling on a Modified Portfolio Diet (MPD) (low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein and 22 g/1000 kcal almonds). Lipid profiles, endothelial function and markers of glycemic control, oxidative stress and inflammation were measured at baseline and following two and four weeks of intervention. Seven patients with no diet therapy served as time controls. Results Consumption of the MPD resulted in a 19% relative reduction in LDL (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L, p < 0.001) with no change in HDL cholesterol. Homocysteine levels dropped significantly (10.1 ± 2.7 vs 7.9 ± 4 μmol/L, p = 0.006) over the study period. Flow mediated dilatation increased significantly in treated patients (3.8 ± 3.8% to 6.5 ± 3.6%, p = 0.004) while remaining constant in controls ( p = 0.6). Endothelial progenitor cells numbers (CD34+, CD 133+ and UEA-1+) increased significantly following MPD consumption ( p < 0.02) with no difference in migratory capacity. In contrast, time controls showed no significant changes. Conclusion Dietary intervention in medically managed, high risk patients resulted in important reductions in risk factors. Clinical Trials registry number NCT00462436.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Cardiovascular risk</subject><subject>Case-Control Studies</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diet therapy</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diet therapy</subject><subject>Diet, Fat-Restricted</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Dietary portfolio</subject><subject>Endothelial function</subject><subject>Endothelial progenitor cells</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>LDL cholesterol</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Patient Compliance</subject><subject>Pilot Projects</subject><subject>Risk Factors</subject><subject>Soybean Proteins - administration & dosage</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1u1TAQhS0EopfCC7BAXrJJGDuJnUgIqar4kyqxANbWXHsCvk3ii-0U9S14ZJzewoIFq5Gscz55zhnGnguoBQj16lDbaVlrCaKtQdUg4AHbia6RlRj65iHbgVSi6pRoz9iTlA4A0DW6f8zOZAeyGaTasV8XfA7Oj54cP4aYxzD5wJ2nzG2YjxPNtOTEZ3Le4sRnXPDb3RvPgUdyqyVuMTofbjDZdcLIo0_XfESbQ0zcLwWGe8re8iNmf0f76fP3go9hwXjLMWYqw_lEmOgpezTilOjZ_TxnX9-9_XL5obr69P7j5cVVZdte5KoFLaEdHMgB9wijGmwPWqteYacF6Q6GtlU4yBYa69CVjYde723TIWEPtjlnL0_cYww_VkrZzD5ZmiZcKKzJCKW7XjcFWqTyJLUxpBRpNMfo5_J1I8BsTZiD2ZowWxMGlClNFNOLe_66L-n9tfyJvghenwRUtrzxFE2yJR5bko5ks3HB_5__5h-7nfyylXRNt5QOYY1Lyc8Ik6QB83m7he0URAsgdNs1vwG3O7Fu</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Keith, Mary</creator><creator>Kuliszewski, Michael A</creator><creator>Liao, Christine</creator><creator>Peeva, Valentina</creator><creator>Ahmed, Mavra</creator><creator>Tran, Susan</creator><creator>Sorokin, Kevin</creator><creator>Jenkins, David J</creator><creator>Errett, Lee</creator><creator>Leong-Poi, Howard</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease</title><author>Keith, Mary ; Kuliszewski, Michael A ; Liao, Christine ; Peeva, Valentina ; Ahmed, Mavra ; Tran, Susan ; Sorokin, Kevin ; Jenkins, David J ; Errett, Lee ; Leong-Poi, Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-4072049d029aba0f69c8077686a571e7509446a92403cdad250987bc35aea80c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Cardiovascular risk</topic><topic>Case-Control Studies</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diet therapy</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diet therapy</topic><topic>Diet, Fat-Restricted</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Dietary portfolio</topic><topic>Endothelial function</topic><topic>Endothelial progenitor cells</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>LDL cholesterol</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>Patient Compliance</topic><topic>Pilot Projects</topic><topic>Risk Factors</topic><topic>Soybean Proteins - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keith, Mary</creatorcontrib><creatorcontrib>Kuliszewski, Michael A</creatorcontrib><creatorcontrib>Liao, Christine</creatorcontrib><creatorcontrib>Peeva, Valentina</creatorcontrib><creatorcontrib>Ahmed, Mavra</creatorcontrib><creatorcontrib>Tran, Susan</creatorcontrib><creatorcontrib>Sorokin, Kevin</creatorcontrib><creatorcontrib>Jenkins, David J</creatorcontrib><creatorcontrib>Errett, Lee</creatorcontrib><creatorcontrib>Leong-Poi, Howard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keith, Mary</au><au>Kuliszewski, Michael A</au><au>Liao, Christine</au><au>Peeva, Valentina</au><au>Ahmed, Mavra</au><au>Tran, Susan</au><au>Sorokin, Kevin</au><au>Jenkins, David J</au><au>Errett, Lee</au><au>Leong-Poi, Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>34</volume><issue>3</issue><spage>541</spage><epage>548</epage><pages>541-548</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>Summary Background & aims Secondary prevention can improve outcomes in high risk patients. This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. Design 30 patients with type II diabetes, 6 weeks post bypass surgery received dietary counseling on a Modified Portfolio Diet (MPD) (low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein and 22 g/1000 kcal almonds). Lipid profiles, endothelial function and markers of glycemic control, oxidative stress and inflammation were measured at baseline and following two and four weeks of intervention. Seven patients with no diet therapy served as time controls. Results Consumption of the MPD resulted in a 19% relative reduction in LDL (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L, p < 0.001) with no change in HDL cholesterol. Homocysteine levels dropped significantly (10.1 ± 2.7 vs 7.9 ± 4 μmol/L, p = 0.006) over the study period. Flow mediated dilatation increased significantly in treated patients (3.8 ± 3.8% to 6.5 ± 3.6%, p = 0.004) while remaining constant in controls ( p = 0.6). Endothelial progenitor cells numbers (CD34+, CD 133+ and UEA-1+) increased significantly following MPD consumption ( p < 0.02) with no difference in migratory capacity. In contrast, time controls showed no significant changes. Conclusion Dietary intervention in medically managed, high risk patients resulted in important reductions in risk factors. Clinical Trials registry number NCT00462436.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25023926</pmid><doi>10.1016/j.clnu.2014.06.010</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical nutrition (Edinburgh, Scotland), 2015-06, Vol.34 (3), p.541-548 |
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| subjects | Aged Biomarkers - blood Blood Glucose - metabolism Cardiovascular risk Case-Control Studies Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Artery Disease - complications Coronary Artery Disease - diet therapy Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diet therapy Diet, Fat-Restricted Dietary Fats - administration & dosage Dietary Fiber - administration & dosage Dietary portfolio Endothelial function Endothelial progenitor cells Energy Intake Female Gastroenterology and Hepatology Homocysteine - blood Humans LDL cholesterol Male Middle Aged Motor Activity Patient Compliance Pilot Projects Risk Factors Soybean Proteins - administration & dosage |
| title | A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease |
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