Lamins: the structure and protein complexes
Lamins are nuclear intermediate filament (IF) proteins. They assemble to fibrous structures that are positioned between the inner nuclear membrane and the peripheral chromatin. A small fraction of lamins is also present in the nucleoplasm. Lamins are required to maintain the nuclear structure and, t...
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| Veröffentlicht in: | Current opinion in cell biology 2015-02, Vol.32, p.7-12 |
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| container_title | Current opinion in cell biology |
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| creator | Gruenbaum, Yosef Medalia, Ohad |
| description | Lamins are nuclear intermediate filament (IF) proteins. They assemble to fibrous structures that are positioned between the inner nuclear membrane and the peripheral chromatin. A small fraction of lamins is also present in the nucleoplasm. Lamins are required to maintain the nuclear structure and, together with their associated proteins, are involved in most nuclear activities. Mutations in lamins cause >14 distinct diseases, called laminopathies, that include heart, muscle, fat and early aging diseases. However, it is not clear how lamins are organized in vivo and how the disease mutations affect lamin organization and functions. Here, we will review structural aspects of lamin assembly, discuss differences between peripheral and nucleoplasmic lamins and describe the protein complexes that lamins form. |
| doi_str_mv | 10.1016/j.ceb.2014.09.009 |
| format | Article |
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| ispartof | Current opinion in cell biology, 2015-02, Vol.32, p.7-12 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Nucleus - metabolism Chromatin - metabolism Humans Internal Medicine Lamins - chemistry Lamins - genetics Lamins - metabolism Mutation Nuclear Envelope - metabolism |
| title | Lamins: the structure and protein complexes |
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