Prognostic Value of FDG PET/CT-Derived Parameters in Pancreatic Adenocarcinoma at Initial PET/CT Staging
The purpose of this study is to evaluate the performance of PET-derived parameters as prognostic markers for overall survival (OS) and progression-free survival (PFS) outcome in patients with pancreatic adenocarcinoma. We conducted a retrospective study of 106 patients (62 men and 44 women) with his...
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| Veröffentlicht in: | American journal of roentgenology (1976) 2015-05, Vol.204 (5), p.1093-1099 |
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| container_title | American journal of roentgenology (1976) |
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| creator | Chirindel, Alin Alluri, Krishna C Chaudhry, Muhammad A Wahl, Richard L Pawlik, Timothy M Herman, Joseph M Subramaniam, Rathan M |
| description | The purpose of this study is to evaluate the performance of PET-derived parameters as prognostic markers for overall survival (OS) and progression-free survival (PFS) outcome in patients with pancreatic adenocarcinoma.
We conducted a retrospective study of 106 patients (62 men and 44 women) with histologically proven pancreatic adenocarcinoma who underwent initial staging FDG PET/CT before treatment. Peak standardized uptake value (SUV), maximum SUV (SUVmax), metabolic tumor volume, and tumor glycolytic activity of the primary pancreatic tumor were measured. Two segmentation methods were performed to obtain the metabolic tumor volume and tumor glycolytic activity for all tumors: a gradient-based segmentation model (metabolic tumor volume and tumor glycolytic activity by gradient edge detection) and a fixed-threshold model with a threshold of 50% of the lesion's SUVmax and peak SUV. Univariate and multivariate Cox regression models were developed including clinical and imaging parameters for OS and PFS.
Multivariate Cox regression analysis showed a statistically significant association between PFS and age, SUVmax, peak SUV, and tumor glycolytic activity by gradient edge detection. There was a statistically significant difference in PFS for patients with values above and below the median cutoff points for SUVmax (hazard ratio [HR], 1.12; p < 0.01), peak SUV (HR, 1.25; p < 0.02), and tumor glycolytic activity measured by gradient edge detection (HR, 1.00; p < 0.02) of the primary tumor. However, multivariate Cox regression analysis showed a statistically significant association only between tumor glycolytic activity by gradient edge detection and OS (p = 0.04), and there was a statistically significant difference in OS between patients with values above and below the median cutoff point for the tumor glycolytic activity by gradient edge detection of the primary tumor (HR, 1.42; p = 0.05).
Age, SUVmax, peak SUV, and total lesion glycolysis (i.e., tumor glycolytic activity) of the primary tumor are associated with PFS, and tumor glycolytic activity is associated with OS in patients with pancreatic adenocarcinoma. |
| doi_str_mv | 10.2214/ajr.14.13156 |
| format | Article |
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We conducted a retrospective study of 106 patients (62 men and 44 women) with histologically proven pancreatic adenocarcinoma who underwent initial staging FDG PET/CT before treatment. Peak standardized uptake value (SUV), maximum SUV (SUVmax), metabolic tumor volume, and tumor glycolytic activity of the primary pancreatic tumor were measured. Two segmentation methods were performed to obtain the metabolic tumor volume and tumor glycolytic activity for all tumors: a gradient-based segmentation model (metabolic tumor volume and tumor glycolytic activity by gradient edge detection) and a fixed-threshold model with a threshold of 50% of the lesion's SUVmax and peak SUV. Univariate and multivariate Cox regression models were developed including clinical and imaging parameters for OS and PFS.
Multivariate Cox regression analysis showed a statistically significant association between PFS and age, SUVmax, peak SUV, and tumor glycolytic activity by gradient edge detection. There was a statistically significant difference in PFS for patients with values above and below the median cutoff points for SUVmax (hazard ratio [HR], 1.12; p < 0.01), peak SUV (HR, 1.25; p < 0.02), and tumor glycolytic activity measured by gradient edge detection (HR, 1.00; p < 0.02) of the primary tumor. However, multivariate Cox regression analysis showed a statistically significant association only between tumor glycolytic activity by gradient edge detection and OS (p = 0.04), and there was a statistically significant difference in OS between patients with values above and below the median cutoff point for the tumor glycolytic activity by gradient edge detection of the primary tumor (HR, 1.42; p = 0.05).
Age, SUVmax, peak SUV, and total lesion glycolysis (i.e., tumor glycolytic activity) of the primary tumor are associated with PFS, and tumor glycolytic activity is associated with OS in patients with pancreatic adenocarcinoma.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/ajr.14.13156</identifier><identifier>PMID: 25905947</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Female ; Fluorodeoxyglucose F18 ; Humans ; Male ; Middle Aged ; Multimodal Imaging ; Neoplasm Staging ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - pathology ; Positron-Emission Tomography ; Prognosis ; Radiographic Image Interpretation, Computer-Assisted ; Radiopharmaceuticals ; Retrospective Studies ; Survival Rate ; Tomography, X-Ray Computed ; Tumor Burden</subject><ispartof>American journal of roentgenology (1976), 2015-05, Vol.204 (5), p.1093-1099</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d961c9dd5016bf0584142a85f361d97ce05112fe205eaf5b3476f4e0237e730c3</citedby><cites>FETCH-LOGICAL-c357t-d961c9dd5016bf0584142a85f361d97ce05112fe205eaf5b3476f4e0237e730c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4120,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25905947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chirindel, Alin</creatorcontrib><creatorcontrib>Alluri, Krishna C</creatorcontrib><creatorcontrib>Chaudhry, Muhammad A</creatorcontrib><creatorcontrib>Wahl, Richard L</creatorcontrib><creatorcontrib>Pawlik, Timothy M</creatorcontrib><creatorcontrib>Herman, Joseph M</creatorcontrib><creatorcontrib>Subramaniam, Rathan M</creatorcontrib><title>Prognostic Value of FDG PET/CT-Derived Parameters in Pancreatic Adenocarcinoma at Initial PET/CT Staging</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>The purpose of this study is to evaluate the performance of PET-derived parameters as prognostic markers for overall survival (OS) and progression-free survival (PFS) outcome in patients with pancreatic adenocarcinoma.
We conducted a retrospective study of 106 patients (62 men and 44 women) with histologically proven pancreatic adenocarcinoma who underwent initial staging FDG PET/CT before treatment. Peak standardized uptake value (SUV), maximum SUV (SUVmax), metabolic tumor volume, and tumor glycolytic activity of the primary pancreatic tumor were measured. Two segmentation methods were performed to obtain the metabolic tumor volume and tumor glycolytic activity for all tumors: a gradient-based segmentation model (metabolic tumor volume and tumor glycolytic activity by gradient edge detection) and a fixed-threshold model with a threshold of 50% of the lesion's SUVmax and peak SUV. Univariate and multivariate Cox regression models were developed including clinical and imaging parameters for OS and PFS.
Multivariate Cox regression analysis showed a statistically significant association between PFS and age, SUVmax, peak SUV, and tumor glycolytic activity by gradient edge detection. There was a statistically significant difference in PFS for patients with values above and below the median cutoff points for SUVmax (hazard ratio [HR], 1.12; p < 0.01), peak SUV (HR, 1.25; p < 0.02), and tumor glycolytic activity measured by gradient edge detection (HR, 1.00; p < 0.02) of the primary tumor. However, multivariate Cox regression analysis showed a statistically significant association only between tumor glycolytic activity by gradient edge detection and OS (p = 0.04), and there was a statistically significant difference in OS between patients with values above and below the median cutoff point for the tumor glycolytic activity by gradient edge detection of the primary tumor (HR, 1.42; p = 0.05).
Age, SUVmax, peak SUV, and total lesion glycolysis (i.e., tumor glycolytic activity) of the primary tumor are associated with PFS, and tumor glycolytic activity is associated with OS in patients with pancreatic adenocarcinoma.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Neoplasm Staging</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Radiopharmaceuticals</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Burden</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AUhQdRbK3uXMssXZh2nplkWfqyIli0irswndzUKcmkzqSC_97UVleHC985cD-ErinpM0bFQG98n4o-5VTGJ6hLpYgjTgU9RV3CYxolhL930EUIG0KISlJ1jjpMpkSmQnXRx8LXa1eHxhr8pssd4LrA0_EMLybLwWgZjcHbL8jxQntdQQM-YOvayxkPel8a5uBqo72xrq401g2eO9tYXR4X8Euj19atL9FZocsAV8fsodfpZDm6jx6fZvPR8DEyXKomytOYmjTPJaHxqiAyEVQwnciifSVPlQEiKWUFMCJBF3LFhYoLAYRxBYoTw3vo9rC79fXnDkKTVTYYKEvtoN6FjMZKJorxJGnRuwNqfB2ChyLbeltp_51Rku3dZsOH56yNX7ctfnNc3q0qyP_hP5n8B-tDcqs</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Chirindel, Alin</creator><creator>Alluri, Krishna C</creator><creator>Chaudhry, Muhammad A</creator><creator>Wahl, Richard L</creator><creator>Pawlik, Timothy M</creator><creator>Herman, Joseph M</creator><creator>Subramaniam, Rathan M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Prognostic Value of FDG PET/CT-Derived Parameters in Pancreatic Adenocarcinoma at Initial PET/CT Staging</title><author>Chirindel, Alin ; Alluri, Krishna C ; Chaudhry, Muhammad A ; Wahl, Richard L ; Pawlik, Timothy M ; Herman, Joseph M ; Subramaniam, Rathan M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d961c9dd5016bf0584142a85f361d97ce05112fe205eaf5b3476f4e0237e730c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Neoplasm Staging</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Positron-Emission Tomography</topic><topic>Prognosis</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Radiopharmaceuticals</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chirindel, Alin</creatorcontrib><creatorcontrib>Alluri, Krishna C</creatorcontrib><creatorcontrib>Chaudhry, Muhammad A</creatorcontrib><creatorcontrib>Wahl, Richard L</creatorcontrib><creatorcontrib>Pawlik, Timothy M</creatorcontrib><creatorcontrib>Herman, Joseph M</creatorcontrib><creatorcontrib>Subramaniam, Rathan M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chirindel, Alin</au><au>Alluri, Krishna C</au><au>Chaudhry, Muhammad A</au><au>Wahl, Richard L</au><au>Pawlik, Timothy M</au><au>Herman, Joseph M</au><au>Subramaniam, Rathan M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of FDG PET/CT-Derived Parameters in Pancreatic Adenocarcinoma at Initial PET/CT Staging</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>2015-05</date><risdate>2015</risdate><volume>204</volume><issue>5</issue><spage>1093</spage><epage>1099</epage><pages>1093-1099</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><abstract>The purpose of this study is to evaluate the performance of PET-derived parameters as prognostic markers for overall survival (OS) and progression-free survival (PFS) outcome in patients with pancreatic adenocarcinoma.
We conducted a retrospective study of 106 patients (62 men and 44 women) with histologically proven pancreatic adenocarcinoma who underwent initial staging FDG PET/CT before treatment. Peak standardized uptake value (SUV), maximum SUV (SUVmax), metabolic tumor volume, and tumor glycolytic activity of the primary pancreatic tumor were measured. Two segmentation methods were performed to obtain the metabolic tumor volume and tumor glycolytic activity for all tumors: a gradient-based segmentation model (metabolic tumor volume and tumor glycolytic activity by gradient edge detection) and a fixed-threshold model with a threshold of 50% of the lesion's SUVmax and peak SUV. Univariate and multivariate Cox regression models were developed including clinical and imaging parameters for OS and PFS.
Multivariate Cox regression analysis showed a statistically significant association between PFS and age, SUVmax, peak SUV, and tumor glycolytic activity by gradient edge detection. There was a statistically significant difference in PFS for patients with values above and below the median cutoff points for SUVmax (hazard ratio [HR], 1.12; p < 0.01), peak SUV (HR, 1.25; p < 0.02), and tumor glycolytic activity measured by gradient edge detection (HR, 1.00; p < 0.02) of the primary tumor. However, multivariate Cox regression analysis showed a statistically significant association only between tumor glycolytic activity by gradient edge detection and OS (p = 0.04), and there was a statistically significant difference in OS between patients with values above and below the median cutoff point for the tumor glycolytic activity by gradient edge detection of the primary tumor (HR, 1.42; p = 0.05).
Age, SUVmax, peak SUV, and total lesion glycolysis (i.e., tumor glycolytic activity) of the primary tumor are associated with PFS, and tumor glycolytic activity is associated with OS in patients with pancreatic adenocarcinoma.</abstract><cop>United States</cop><pmid>25905947</pmid><doi>10.2214/ajr.14.13156</doi><tpages>7</tpages></addata></record> |
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| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Adult Aged Aged, 80 and over Female Fluorodeoxyglucose F18 Humans Male Middle Aged Multimodal Imaging Neoplasm Staging Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - pathology Positron-Emission Tomography Prognosis Radiographic Image Interpretation, Computer-Assisted Radiopharmaceuticals Retrospective Studies Survival Rate Tomography, X-Ray Computed Tumor Burden |
| title | Prognostic Value of FDG PET/CT-Derived Parameters in Pancreatic Adenocarcinoma at Initial PET/CT Staging |
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