The delay time in sickle cell disease after 40 years: A paradigm assessed

Sickle hemoglobin polymerization commences with a striking latency period, called a “delay time” followed by abrupt polymer formation. The delay time is exceedingly concentration dependent. This discovery (40 years ago) led to the “kinetic hypothesis,” that is, that the pathophysiology was related t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of hematology 2015-05, Vol.90 (5), p.438-445
1. Verfasser:	Ferrone, Frank A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - blood Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - drug therapy Anemia, Sickle Cell - pathology Antisickling Agents - therapeutic use Cell Movement - drug effects Erythrocyte Deformability - drug effects Erythrocytes, Abnormal - drug effects Erythrocytes, Abnormal - metabolism Erythrocytes, Abnormal - pathology Hematology Hemoglobin, Sickle - antagonists & inhibitors Hemoglobin, Sickle - chemistry Hemoglobin, Sickle - metabolism Humans Hydroxyurea - therapeutic use Kinetics Lung - blood supply Lung - drug effects Lung - metabolism Lung - pathology Oxygen - blood Polymerization - drug effects Severity of Illness Index Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!