HSF1 transcriptional activity is modulated by IER5 and PP2A/B55

•IER5, a target gene of HSF1, interacts with PP2A and its B55 regulatory subunits.•IER5 and B55 enhance HSF1 dephosphorylation and expression of HSF1 target genes.•IER5 functions as a positive feedback regulator of HSF1.•This process involves PP2A/B55 and HSF1 dephosphorylation. Heat shock factor 1...

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Veröffentlicht in:	FEBS letters 2015-04, Vol.589 (10), p.1150-1155
Hauptverfasser:	Ishikawa, Yukio, Kawabata, Shotaro, Sakurai, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Chaperone DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation - physiology Heat shock factor 1 Heat Shock Transcription Factors HeLa Cells Humans IER5 Immediate-early gene Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphorylation Phosphorylation - physiology Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Protein phosphatase 2A Transcription Factors - genetics Transcription Factors - metabolism
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