Upregulation of P-glycoprotein expression by ophthalmic drugs in different corneal in-vitro models

Objectives The purpose of this study was to analyse P‐glycoprotein (P‐gp) expression in different human in‐vitro cornea models (HCE‐T epithelial model and Hemicornea construct) after stimulation with P‐gp substrates (rhodamine 123, levofloxacin and acebutolol). Methods The influence of P‐gp substrat...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2015-05, Vol.67 (5), p.605-615
Hauptverfasser:	Verstraelen, Jessica, Reichl, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acebutolol - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis biopharmaceutics and drug disposition Cells, Cultured cellular drug uptake and absorption Cornea - drug effects Cornea - metabolism Humans In Vitro Techniques Levofloxacin - pharmacology Medical research Ophthalmic Solutions - pharmacology other topics Rhodamine 123 - pharmacology Up-Regulation - drug effects
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