Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events
ABSTRACT Dual‐energy x‐ray absorptiometry (DXA) is the gold standard method for measuring periprosthetic bone remodeling, but relies on a region of interest (ROI) analysis approach. While this addresses issues of anatomic variability, it is insensitive to bone remodeling events at the sub‐ROI level....
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| Veröffentlicht in: | Journal of orthopaedic research 2015-05, Vol.33 (5), p.712-716 |
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| creator | Wilkinson, J. Mark Morris, Richard M. Martin-Fernandez, Miguel A. Pozo, Jose M. Frangi, Alejandro F. Maheson, Marci Yang, Lang |
| description | ABSTRACT
Dual‐energy x‐ray absorptiometry (DXA) is the gold standard method for measuring periprosthetic bone remodeling, but relies on a region of interest (ROI) analysis approach. While this addresses issues of anatomic variability, it is insensitive to bone remodeling events at the sub‐ROI level. We have validated a high‐spatial resolution tool, termed DXA‐region free analysis (DXA‐RFA) that uses advanced image processing approaches to allow quantitation of bone mineral density (BMD) at the individual pixel (data‐point) level. Here we compared the resolution of bone remodeling measurements made around a stemless femoral prosthesis in 18 subjects over 24 months using ROI‐based analysis versus that made using DXA‐RFA. Using the ROI approach the regional pattern of BMD change varied by region, with greatest loss in ROI5 (20%, p |
| doi_str_mv | 10.1002/jor.22823 |
| format | Article |
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Dual‐energy x‐ray absorptiometry (DXA) is the gold standard method for measuring periprosthetic bone remodeling, but relies on a region of interest (ROI) analysis approach. While this addresses issues of anatomic variability, it is insensitive to bone remodeling events at the sub‐ROI level. We have validated a high‐spatial resolution tool, termed DXA‐region free analysis (DXA‐RFA) that uses advanced image processing approaches to allow quantitation of bone mineral density (BMD) at the individual pixel (data‐point) level. Here we compared the resolution of bone remodeling measurements made around a stemless femoral prosthesis in 18 subjects over 24 months using ROI‐based analysis versus that made using DXA‐RFA. Using the ROI approach the regional pattern of BMD change varied by region, with greatest loss in ROI5 (20%, p < 0.001), and largest gain in ROI4 (6%, p < 0.05). Analysis using DXA‐RFA showed a focal zone of increased BMD localized to the prosthesis–bone interface (30–40%, p < 0.001) that was not resolved using conventional DXA analysis. The 20% bone loss observed in ROI5 with conventional DXA was resolved to a focal area adjacent to the cut surface of the infero‐medial femoral neck (up to 40%, p < 0.0001). DXA‐RFA enables high resolution analysis of DXA datasets without the limitations incurred using ROI‐based approaches. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:712–716, 2015.</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.22823</identifier><identifier>PMID: 25640686</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Absorptiometry, Photon ; Arthroplasty, Replacement, Hip ; bone mineral density ; Bone Remodeling ; dual-energy x-ray absorptiometry region free analysis ; Female ; femur ; Hip Prosthesis ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Prospective Studies ; total hip arthroplasty</subject><ispartof>Journal of orthopaedic research, 2015-05, Vol.33 (5), p.712-716</ispartof><rights>2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3983-a82e8c5c69e8a41988a94c484c61debe048e882904a755c992a0bd5ab3c781693</citedby><cites>FETCH-LOGICAL-c3983-a82e8c5c69e8a41988a94c484c61debe048e882904a755c992a0bd5ab3c781693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjor.22823$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjor.22823$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25640686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilkinson, J. Mark</creatorcontrib><creatorcontrib>Morris, Richard M.</creatorcontrib><creatorcontrib>Martin-Fernandez, Miguel A.</creatorcontrib><creatorcontrib>Pozo, Jose M.</creatorcontrib><creatorcontrib>Frangi, Alejandro F.</creatorcontrib><creatorcontrib>Maheson, Marci</creatorcontrib><creatorcontrib>Yang, Lang</creatorcontrib><title>Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>ABSTRACT
Dual‐energy x‐ray absorptiometry (DXA) is the gold standard method for measuring periprosthetic bone remodeling, but relies on a region of interest (ROI) analysis approach. While this addresses issues of anatomic variability, it is insensitive to bone remodeling events at the sub‐ROI level. We have validated a high‐spatial resolution tool, termed DXA‐region free analysis (DXA‐RFA) that uses advanced image processing approaches to allow quantitation of bone mineral density (BMD) at the individual pixel (data‐point) level. Here we compared the resolution of bone remodeling measurements made around a stemless femoral prosthesis in 18 subjects over 24 months using ROI‐based analysis versus that made using DXA‐RFA. Using the ROI approach the regional pattern of BMD change varied by region, with greatest loss in ROI5 (20%, p < 0.001), and largest gain in ROI4 (6%, p < 0.05). Analysis using DXA‐RFA showed a focal zone of increased BMD localized to the prosthesis–bone interface (30–40%, p < 0.001) that was not resolved using conventional DXA analysis. The 20% bone loss observed in ROI5 with conventional DXA was resolved to a focal area adjacent to the cut surface of the infero‐medial femoral neck (up to 40%, p < 0.0001). DXA‐RFA enables high resolution analysis of DXA datasets without the limitations incurred using ROI‐based approaches. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:712–716, 2015.</description><subject>Absorptiometry, Photon</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>bone mineral density</subject><subject>Bone Remodeling</subject><subject>dual-energy x-ray absorptiometry region free analysis</subject><subject>Female</subject><subject>femur</subject><subject>Hip Prosthesis</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>total hip arthroplasty</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAQhi0EotuFAy-AfGwPbm0ndpzjaqFbqopKFYXeLMeZ3XVx4q3tQPMOPDQp2_bGaQ7z_f-MPoQ-MHrCKOWndyGecK548QrNmBAlEby6fY1mtCokoVzKA3SY0h2ltGJcvUUHXMiSSiVn6M9NAhzWeOs2WxwhBT9kF3rcDsYT6CFuRvxAohmxaVKIu2nZQY4jibB55NYRAJve-DG5hI8-3S7I9dniGOeAW8hgM_bBGo93EN0uhpS3kJ3FTehhOteFFrzrNxh-QZ_TO_RmbXyC909zjm7OPn9bnpPLq9WX5eKS2KJWBTGKg7LCyhqUKVmtlKlLW6rSStZCA7RUoBSvaWkqIWxdc0ObVpimsJVisi7m6GjfO310P0DKunPJgvemhzAkzWQlJo5N_uboeI_a6fkUYa130XUmjppR_ShfT_L1P_kT-_Gpdmg6aF_IZ9sTcLoHfjsP4_-b9MXV9XMl2SdcyvDwkjDxp5ZVUQn94-tK18vV6qJi37Us_gJbiJ8Q</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Wilkinson, J. Mark</creator><creator>Morris, Richard M.</creator><creator>Martin-Fernandez, Miguel A.</creator><creator>Pozo, Jose M.</creator><creator>Frangi, Alejandro F.</creator><creator>Maheson, Marci</creator><creator>Yang, Lang</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events</title><author>Wilkinson, J. Mark ; Morris, Richard M. ; Martin-Fernandez, Miguel A. ; Pozo, Jose M. ; Frangi, Alejandro F. ; Maheson, Marci ; Yang, Lang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3983-a82e8c5c69e8a41988a94c484c61debe048e882904a755c992a0bd5ab3c781693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Absorptiometry, Photon</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>bone mineral density</topic><topic>Bone Remodeling</topic><topic>dual-energy x-ray absorptiometry region free analysis</topic><topic>Female</topic><topic>femur</topic><topic>Hip Prosthesis</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>total hip arthroplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilkinson, J. Mark</creatorcontrib><creatorcontrib>Morris, Richard M.</creatorcontrib><creatorcontrib>Martin-Fernandez, Miguel A.</creatorcontrib><creatorcontrib>Pozo, Jose M.</creatorcontrib><creatorcontrib>Frangi, Alejandro F.</creatorcontrib><creatorcontrib>Maheson, Marci</creatorcontrib><creatorcontrib>Yang, Lang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilkinson, J. Mark</au><au>Morris, Richard M.</au><au>Martin-Fernandez, Miguel A.</au><au>Pozo, Jose M.</au><au>Frangi, Alejandro F.</au><au>Maheson, Marci</au><au>Yang, Lang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J. Orthop. Res</addtitle><date>2015-05</date><risdate>2015</risdate><volume>33</volume><issue>5</issue><spage>712</spage><epage>716</epage><pages>712-716</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><abstract>ABSTRACT
Dual‐energy x‐ray absorptiometry (DXA) is the gold standard method for measuring periprosthetic bone remodeling, but relies on a region of interest (ROI) analysis approach. While this addresses issues of anatomic variability, it is insensitive to bone remodeling events at the sub‐ROI level. We have validated a high‐spatial resolution tool, termed DXA‐region free analysis (DXA‐RFA) that uses advanced image processing approaches to allow quantitation of bone mineral density (BMD) at the individual pixel (data‐point) level. Here we compared the resolution of bone remodeling measurements made around a stemless femoral prosthesis in 18 subjects over 24 months using ROI‐based analysis versus that made using DXA‐RFA. Using the ROI approach the regional pattern of BMD change varied by region, with greatest loss in ROI5 (20%, p < 0.001), and largest gain in ROI4 (6%, p < 0.05). Analysis using DXA‐RFA showed a focal zone of increased BMD localized to the prosthesis–bone interface (30–40%, p < 0.001) that was not resolved using conventional DXA analysis. The 20% bone loss observed in ROI5 with conventional DXA was resolved to a focal area adjacent to the cut surface of the infero‐medial femoral neck (up to 40%, p < 0.0001). DXA‐RFA enables high resolution analysis of DXA datasets without the limitations incurred using ROI‐based approaches. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:712–716, 2015.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25640686</pmid><doi>10.1002/jor.22823</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Arthroplasty, Replacement, Hip bone mineral density Bone Remodeling dual-energy x-ray absorptiometry region free analysis Female femur Hip Prosthesis Humans Image Processing, Computer-Assisted Male Middle Aged Prospective Studies total hip arthroplasty |
| title | Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events |
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