Defining the histopathological changes induced by nonablative radiofrequency treatment of faecal incontinence - a blinded assessment in an animal model

Aim Nonablative radiofrequency (RF) sphincter remodelling has been used to treat gastro‐oesophageal reflux disease (GERD) and faecal incontinence (FI). Its mechanism of action is unclear. We aimed to investigate the histomorphological and pathophysiological changes to the internal and external anal...

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Veröffentlicht in:	Colorectal disease 2015-05, Vol.17 (5), p.433-440
Hauptverfasser:	Herman, R. M., Berho, M., Murawski, M., Nowakowski, M., Ryś, J., Schwarz, T., Wojtysiak, D., Wexner, S. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anal Canal - metabolism Anal Canal - pathology Animals Collagen Type I - metabolism Collagen Type III - metabolism Connective Tissue - metabolism Connective Tissue - pathology Disease Models, Animal Faecal incontinence Fecal Incontinence - pathology Fecal Incontinence - therapy Female Manometry Muscle, Smooth - metabolism Muscle, Smooth - pathology Pulsed Radiofrequency Treatment - methods radiofrequency anal remodelling Single-Blind Method sphincter morphology Swine
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