Multicenter evaluation of dynamic three-dimensional magnetic resonance myocardial perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve
First-pass myocardial perfusion cardiovascular magnetic resonance (CMR) imaging yields high diagnostic accuracy for the detection of coronary artery disease (CAD). However, standard 2D multislice CMR perfusion techniques provide only limited cardiac coverage, and hence considerable assumptions are r...
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| Veröffentlicht in: | Circulation. Cardiovascular imaging 2015-05, Vol.8 (5) |
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| creator | Manka, Robert Wissmann, Lukas Gebker, Rolf Jogiya, Roy Motwani, Manish Frick, Michael Reinartz, Sebastian Schnackenburg, Bernhard Niemann, Markus Gotschy, Alexander Kuhl, Christiane Nagel, Eike Fleck, Eckart Marx, Nikolaus Luescher, Thomas F Plein, Sven Kozerke, Sebastian |
| description | First-pass myocardial perfusion cardiovascular magnetic resonance (CMR) imaging yields high diagnostic accuracy for the detection of coronary artery disease (CAD). However, standard 2D multislice CMR perfusion techniques provide only limited cardiac coverage, and hence considerable assumptions are required to assess myocardial ischemic burden. The aim of this prospective study was to assess the diagnostic performance of 3D myocardial perfusion CMR to detect functionally relevant CAD with fractional flow reserve (FFR) as a reference standard in a multicenter setting.
A total of 155 patients with suspected CAD listed for coronary angiography with FFR were prospectively enrolled from 5 European centers. 3D perfusion CMR was acquired on 3T MR systems from a single vendor under adenosine stress and at rest. All CMR perfusion analyses were performed in a central laboratory and blinded to all clinical data. One hundred fifty patients were successfully examined (mean age 62.9±10 years, 45 female). The prevalence of CAD defined by FFR ( |
| doi_str_mv | 10.1161/circimaging.114.003061 |
| format | Article |
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A total of 155 patients with suspected CAD listed for coronary angiography with FFR were prospectively enrolled from 5 European centers. 3D perfusion CMR was acquired on 3T MR systems from a single vendor under adenosine stress and at rest. All CMR perfusion analyses were performed in a central laboratory and blinded to all clinical data. One hundred fifty patients were successfully examined (mean age 62.9±10 years, 45 female). The prevalence of CAD defined by FFR (<0.8) was 56.7% (85 of 150 patients). The sensitivity and specificity of 3D perfusion CMR were 84.7% and 90.8% relative to the FFR reference. Comparison to quantitative coronary angiography (≥50%) yielded a prevalence of 65.3%, sensitivity and specificity of 76.5% and 94.2%, respectively.
In this multicenter study, 3D myocardial perfusion CMR proved highly diagnostic for the detection of significant CAD as defined by FFR.</description><identifier>ISSN: 1941-9651</identifier><identifier>EISSN: 1942-0080</identifier><identifier>DOI: 10.1161/circimaging.114.003061</identifier><identifier>PMID: 25901043</identifier><language>eng</language><publisher>United States</publisher><subject>Adenosine ; Coronary Angiography ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - physiopathology ; Coronary Circulation ; Europe ; Exercise Test ; Female ; Fractional Flow Reserve, Myocardial ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Angiography - methods ; Magnetic Resonance Imaging, Cine - methods ; Male ; Middle Aged ; Myocardial Perfusion Imaging - methods ; Prospective Studies ; Sensitivity and Specificity</subject><ispartof>Circulation. Cardiovascular imaging, 2015-05, Vol.8 (5)</ispartof><rights>2015 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-a767b6ad50e5717f7754d2b8e163d28467350e01c291ef8f9c37cdb527ca8cf3</citedby><cites>FETCH-LOGICAL-c425t-a767b6ad50e5717f7754d2b8e163d28467350e01c291ef8f9c37cdb527ca8cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25901043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manka, Robert</creatorcontrib><creatorcontrib>Wissmann, Lukas</creatorcontrib><creatorcontrib>Gebker, Rolf</creatorcontrib><creatorcontrib>Jogiya, Roy</creatorcontrib><creatorcontrib>Motwani, Manish</creatorcontrib><creatorcontrib>Frick, Michael</creatorcontrib><creatorcontrib>Reinartz, Sebastian</creatorcontrib><creatorcontrib>Schnackenburg, Bernhard</creatorcontrib><creatorcontrib>Niemann, Markus</creatorcontrib><creatorcontrib>Gotschy, Alexander</creatorcontrib><creatorcontrib>Kuhl, Christiane</creatorcontrib><creatorcontrib>Nagel, Eike</creatorcontrib><creatorcontrib>Fleck, Eckart</creatorcontrib><creatorcontrib>Marx, Nikolaus</creatorcontrib><creatorcontrib>Luescher, Thomas F</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Kozerke, Sebastian</creatorcontrib><title>Multicenter evaluation of dynamic three-dimensional magnetic resonance myocardial perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve</title><title>Circulation. Cardiovascular imaging</title><addtitle>Circ Cardiovasc Imaging</addtitle><description>First-pass myocardial perfusion cardiovascular magnetic resonance (CMR) imaging yields high diagnostic accuracy for the detection of coronary artery disease (CAD). However, standard 2D multislice CMR perfusion techniques provide only limited cardiac coverage, and hence considerable assumptions are required to assess myocardial ischemic burden. The aim of this prospective study was to assess the diagnostic performance of 3D myocardial perfusion CMR to detect functionally relevant CAD with fractional flow reserve (FFR) as a reference standard in a multicenter setting.
A total of 155 patients with suspected CAD listed for coronary angiography with FFR were prospectively enrolled from 5 European centers. 3D perfusion CMR was acquired on 3T MR systems from a single vendor under adenosine stress and at rest. All CMR perfusion analyses were performed in a central laboratory and blinded to all clinical data. One hundred fifty patients were successfully examined (mean age 62.9±10 years, 45 female). The prevalence of CAD defined by FFR (<0.8) was 56.7% (85 of 150 patients). The sensitivity and specificity of 3D perfusion CMR were 84.7% and 90.8% relative to the FFR reference. Comparison to quantitative coronary angiography (≥50%) yielded a prevalence of 65.3%, sensitivity and specificity of 76.5% and 94.2%, respectively.
In this multicenter study, 3D myocardial perfusion CMR proved highly diagnostic for the detection of significant CAD as defined by FFR.</description><subject>Adenosine</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Circulation</subject><subject>Europe</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>1941-9651</issn><issn>1942-0080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UV1P3SAYJsZFndtfMFzupgptgfbSnOjxJLoli_cNhRfH0sLZS6vp7_IPyvlwV5DnE_IQcsXZNeeS3xiPxo_6xYeXDNTXjFVM8hNywdu6LBhr2On-zotWCn5Ovqb0lzFZMdGckfNStIyzurog70_zMHkDYQKk8KqHWU8-BhodtUvQozd0-oMAhfUjhJQpPdDcGyC7KELKQDBAxyUajdZndgvo5p2SHh9IXcScAtTCBOYz3kTMXlyoxty9UOsT6LQTOR_A0n6hDvVenkPdEN92dYCv8I18cXpI8P14XpLn-7vn1UPx-Gu9Wd0-FqYuxVRoJVUvtRUMhOLKKSVqW_YNcFnZsqmlqjLFuClbDq5xramUsb0oldGNcdUl-XGI3WL8N0OautEnA8OgA8Q5dVwqwWVTyiZL5UFqMKaE4Lot5s_j0nHW7fbqVpvfq83T7Xrzc52BujvslY1Xx465H8H-t30OVH0ATJeZEA</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Manka, Robert</creator><creator>Wissmann, Lukas</creator><creator>Gebker, Rolf</creator><creator>Jogiya, Roy</creator><creator>Motwani, Manish</creator><creator>Frick, Michael</creator><creator>Reinartz, Sebastian</creator><creator>Schnackenburg, Bernhard</creator><creator>Niemann, Markus</creator><creator>Gotschy, Alexander</creator><creator>Kuhl, Christiane</creator><creator>Nagel, Eike</creator><creator>Fleck, Eckart</creator><creator>Marx, Nikolaus</creator><creator>Luescher, Thomas F</creator><creator>Plein, Sven</creator><creator>Kozerke, Sebastian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Multicenter evaluation of dynamic three-dimensional magnetic resonance myocardial perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve</title><author>Manka, Robert ; Wissmann, Lukas ; Gebker, Rolf ; Jogiya, Roy ; Motwani, Manish ; Frick, Michael ; Reinartz, Sebastian ; Schnackenburg, Bernhard ; Niemann, Markus ; Gotschy, Alexander ; Kuhl, Christiane ; Nagel, Eike ; Fleck, Eckart ; Marx, Nikolaus ; Luescher, Thomas F ; Plein, Sven ; Kozerke, Sebastian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-a767b6ad50e5717f7754d2b8e163d28467350e01c291ef8f9c37cdb527ca8cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenosine</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Circulation</topic><topic>Europe</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fractional Flow Reserve, Myocardial</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Magnetic Resonance Imaging, Cine - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manka, Robert</creatorcontrib><creatorcontrib>Wissmann, Lukas</creatorcontrib><creatorcontrib>Gebker, Rolf</creatorcontrib><creatorcontrib>Jogiya, Roy</creatorcontrib><creatorcontrib>Motwani, Manish</creatorcontrib><creatorcontrib>Frick, Michael</creatorcontrib><creatorcontrib>Reinartz, Sebastian</creatorcontrib><creatorcontrib>Schnackenburg, Bernhard</creatorcontrib><creatorcontrib>Niemann, Markus</creatorcontrib><creatorcontrib>Gotschy, Alexander</creatorcontrib><creatorcontrib>Kuhl, Christiane</creatorcontrib><creatorcontrib>Nagel, Eike</creatorcontrib><creatorcontrib>Fleck, Eckart</creatorcontrib><creatorcontrib>Marx, Nikolaus</creatorcontrib><creatorcontrib>Luescher, Thomas F</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Kozerke, Sebastian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manka, Robert</au><au>Wissmann, Lukas</au><au>Gebker, Rolf</au><au>Jogiya, Roy</au><au>Motwani, Manish</au><au>Frick, Michael</au><au>Reinartz, Sebastian</au><au>Schnackenburg, Bernhard</au><au>Niemann, Markus</au><au>Gotschy, Alexander</au><au>Kuhl, Christiane</au><au>Nagel, Eike</au><au>Fleck, Eckart</au><au>Marx, Nikolaus</au><au>Luescher, Thomas F</au><au>Plein, Sven</au><au>Kozerke, Sebastian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multicenter evaluation of dynamic three-dimensional magnetic resonance myocardial perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve</atitle><jtitle>Circulation. Cardiovascular imaging</jtitle><addtitle>Circ Cardiovasc Imaging</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>8</volume><issue>5</issue><issn>1941-9651</issn><eissn>1942-0080</eissn><abstract>First-pass myocardial perfusion cardiovascular magnetic resonance (CMR) imaging yields high diagnostic accuracy for the detection of coronary artery disease (CAD). However, standard 2D multislice CMR perfusion techniques provide only limited cardiac coverage, and hence considerable assumptions are required to assess myocardial ischemic burden. The aim of this prospective study was to assess the diagnostic performance of 3D myocardial perfusion CMR to detect functionally relevant CAD with fractional flow reserve (FFR) as a reference standard in a multicenter setting.
A total of 155 patients with suspected CAD listed for coronary angiography with FFR were prospectively enrolled from 5 European centers. 3D perfusion CMR was acquired on 3T MR systems from a single vendor under adenosine stress and at rest. All CMR perfusion analyses were performed in a central laboratory and blinded to all clinical data. One hundred fifty patients were successfully examined (mean age 62.9±10 years, 45 female). The prevalence of CAD defined by FFR (<0.8) was 56.7% (85 of 150 patients). The sensitivity and specificity of 3D perfusion CMR were 84.7% and 90.8% relative to the FFR reference. Comparison to quantitative coronary angiography (≥50%) yielded a prevalence of 65.3%, sensitivity and specificity of 76.5% and 94.2%, respectively.
In this multicenter study, 3D myocardial perfusion CMR proved highly diagnostic for the detection of significant CAD as defined by FFR.</abstract><cop>United States</cop><pmid>25901043</pmid><doi>10.1161/circimaging.114.003061</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1941-9651 |
| ispartof | Circulation. Cardiovascular imaging, 2015-05, Vol.8 (5) |
| issn | 1941-9651 1942-0080 |
| language | eng |
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| source | MEDLINE; American Heart Association; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenosine Coronary Angiography Coronary Artery Disease - diagnosis Coronary Artery Disease - physiopathology Coronary Circulation Europe Exercise Test Female Fractional Flow Reserve, Myocardial Humans Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Angiography - methods Magnetic Resonance Imaging, Cine - methods Male Middle Aged Myocardial Perfusion Imaging - methods Prospective Studies Sensitivity and Specificity |
| title | Multicenter evaluation of dynamic three-dimensional magnetic resonance myocardial perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve |
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