Chemotherapy of WAP‐T mouse mammary carcinomas aggravates tumor phenotype and enhances tumor cell dissemination

In this study, the effects of the standard chemotherapy, cyclophosphamide/adriamycin/5‐fluorouracil (CAF) on tumor growth, dissemination and recurrence after orthotopic implantation of murine G‐2 cells were analyzed in the syngeneic immunocompetent whey acidic protein‐T mouse model (Wegwitz et al.,...

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Veröffentlicht in:	International journal of cancer 2015-07, Vol.137 (1), p.25-36
Hauptverfasser:	Jannasch, Katharina, Wegwitz, Florian, Lenfert, Eva, Maenz, Claudia, Deppert, Wolfgang, Alves, Frauke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage breast cancer Cancer Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cyclophosphamide - administration & dosage Cyclophosphamide - pharmacology disseminated tumor cells Doxorubicin - administration & dosage Doxorubicin - pharmacology Epithelial-Mesenchymal Transition - drug effects Female Fluorouracil - administration & dosage Fluorouracil - pharmacology Gene Expression Regulation, Neoplastic - drug effects Genotype & phenotype Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Medical research Mice Neoplasm Recurrence, Local - pathology Neoplasm Transplantation Neoplasm, Residual - pathology recurrent tumor growth transgenic tumor mouse models Tumors
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