Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs
The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in nati...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2015-03, Vol.33 (2), p.141-145 |
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| creator | Montoro Alvarez, Maria Chong, Ong Yew Janta, Iustina González, Carlos López-Longo, Javier Monteagudo, Indalecio Valor, Larissa Garrido, Jesús Lau, Ing Soo Rosman, Azmillah Naredo, Esperanza Carreño, Luis |
| description | The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in native complement component levels in RA patients on biologic therapy.
This was a cross-sectional study. Ninety-seven consecutive patients with RA on biologic therapy for at least 3 months were recruited. Clinical, laboratory and Doppler US assessments were performed. The Disease Activity Score in 28 joints (DAS28), Simplified Disease Activity Index (SDAI) and a 12-joint US assessment were carried out. Synovitis was semiquantitatively scored in B-mode and power Doppler (PD) mode.
A significant decrease in native complement (i.e. C3 and C4) and C-reactive protein (CRP) levels was observed. This was highly significant for C3 decrease (p |
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This was a cross-sectional study. Ninety-seven consecutive patients with RA on biologic therapy for at least 3 months were recruited. Clinical, laboratory and Doppler US assessments were performed. The Disease Activity Score in 28 joints (DAS28), Simplified Disease Activity Index (SDAI) and a 12-joint US assessment were carried out. Synovitis was semiquantitatively scored in B-mode and power Doppler (PD) mode.
A significant decrease in native complement (i.e. C3 and C4) and C-reactive protein (CRP) levels was observed. This was highly significant for C3 decrease (p<0.0005), and C4 decrease (p<0.0005). Synovitis detected by PD US showed significant negative association with C3 change (p<0.008), where patients with higher C3 change were more likely to have PD US inactive status on assessment.
Our results suggested that disease inactive status determined by PD US but not by clinical assessment can be related with decrease in complement in RA patients treated with biologic therapy.</description><identifier>ISSN: 0392-856X</identifier><identifier>PMID: 25665178</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - diagnostic imaging ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - immunology ; Biological Products - therapeutic use ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Complement Activation - drug effects ; Complement System Proteins - metabolism ; Cross-Sectional Studies ; Female ; Humans ; Inflammation Mediators - blood ; Male ; Middle Aged ; Predictive Value of Tests ; Remission Induction ; Severity of Illness Index ; Synovial Membrane - diagnostic imaging ; Synovial Membrane - drug effects ; Synovial Membrane - immunology ; Synovitis - diagnostic imaging ; Synovitis - drug therapy ; Synovitis - immunology ; Time Factors ; Treatment Outcome ; Ultrasonography, Doppler ; Young Adult</subject><ispartof>Clinical and experimental rheumatology, 2015-03, Vol.33 (2), p.141-145</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25665178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montoro Alvarez, Maria</creatorcontrib><creatorcontrib>Chong, Ong Yew</creatorcontrib><creatorcontrib>Janta, Iustina</creatorcontrib><creatorcontrib>González, Carlos</creatorcontrib><creatorcontrib>López-Longo, Javier</creatorcontrib><creatorcontrib>Monteagudo, Indalecio</creatorcontrib><creatorcontrib>Valor, Larissa</creatorcontrib><creatorcontrib>Garrido, Jesús</creatorcontrib><creatorcontrib>Lau, Ing Soo</creatorcontrib><creatorcontrib>Rosman, Azmillah</creatorcontrib><creatorcontrib>Naredo, Esperanza</creatorcontrib><creatorcontrib>Carreño, Luis</creatorcontrib><title>Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in native complement component levels in RA patients on biologic therapy.
This was a cross-sectional study. Ninety-seven consecutive patients with RA on biologic therapy for at least 3 months were recruited. Clinical, laboratory and Doppler US assessments were performed. The Disease Activity Score in 28 joints (DAS28), Simplified Disease Activity Index (SDAI) and a 12-joint US assessment were carried out. Synovitis was semiquantitatively scored in B-mode and power Doppler (PD) mode.
A significant decrease in native complement (i.e. C3 and C4) and C-reactive protein (CRP) levels was observed. This was highly significant for C3 decrease (p<0.0005), and C4 decrease (p<0.0005). Synovitis detected by PD US showed significant negative association with C3 change (p<0.008), where patients with higher C3 change were more likely to have PD US inactive status on assessment.
Our results suggested that disease inactive status determined by PD US but not by clinical assessment can be related with decrease in complement in RA patients treated with biologic therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Biological Products - therapeutic use</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Complement Activation - drug effects</subject><subject>Complement System Proteins - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Remission Induction</subject><subject>Severity of Illness Index</subject><subject>Synovial Membrane - diagnostic imaging</subject><subject>Synovial Membrane - drug effects</subject><subject>Synovial Membrane - immunology</subject><subject>Synovitis - diagnostic imaging</subject><subject>Synovitis - drug therapy</subject><subject>Synovitis - immunology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Doppler</subject><subject>Young Adult</subject><issn>0392-856X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkctKxDAUhrtQnPHyCpKlm0KatGm6lPEKA4IouCtpctqJpElN0so8py9k5yK4Oj_83_9tzkmyxLQiKS_YxyI5D-ETY8IKVp4lC1IwVmQlXyY_r2BE1M4i16I7NwwGPBpN9CK40SoUttZNOuqAJvBhDEgabbUU5l_zreMGyY2wHQSkLbKzcAIkXT_berBxH53dJQMTmD3lNzD2IjqtkPBx4_eqYZ7OWEDRg4igDu5GO-M6LZHSAUSAtHdKt1ttOyRs1OlRtQP82IXL5LQVJsDV8V4k7w_3b6undP3y-Ly6XacDybKYEipboTDDFBeFqgjwpi0VaWSV01JghTOcK2ioZFxVnIoWt0XWcEVY3hIpBb1Ibg7ewbuvEUKsex0kGCMsuDHUGSvzimWY8xm9PqJj04OqB6974bf13yPoL1lpjJA</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Montoro Alvarez, Maria</creator><creator>Chong, Ong Yew</creator><creator>Janta, Iustina</creator><creator>González, Carlos</creator><creator>López-Longo, Javier</creator><creator>Monteagudo, Indalecio</creator><creator>Valor, Larissa</creator><creator>Garrido, Jesús</creator><creator>Lau, Ing Soo</creator><creator>Rosman, Azmillah</creator><creator>Naredo, Esperanza</creator><creator>Carreño, Luis</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs</title><author>Montoro Alvarez, Maria ; Chong, Ong Yew ; Janta, Iustina ; González, Carlos ; López-Longo, Javier ; Monteagudo, Indalecio ; Valor, Larissa ; Garrido, Jesús ; Lau, Ing Soo ; Rosman, Azmillah ; Naredo, Esperanza ; Carreño, Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-23cfad0603055d92e8bf7d2bc9437a0d0104deb3c68d983af0f51b8d264f2cca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Biological Products - therapeutic use</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Complement Activation - drug effects</topic><topic>Complement System Proteins - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Remission Induction</topic><topic>Severity of Illness Index</topic><topic>Synovial Membrane - diagnostic imaging</topic><topic>Synovial Membrane - drug effects</topic><topic>Synovial Membrane - immunology</topic><topic>Synovitis - diagnostic imaging</topic><topic>Synovitis - drug therapy</topic><topic>Synovitis - immunology</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Doppler</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montoro Alvarez, Maria</creatorcontrib><creatorcontrib>Chong, Ong Yew</creatorcontrib><creatorcontrib>Janta, Iustina</creatorcontrib><creatorcontrib>González, Carlos</creatorcontrib><creatorcontrib>López-Longo, Javier</creatorcontrib><creatorcontrib>Monteagudo, Indalecio</creatorcontrib><creatorcontrib>Valor, Larissa</creatorcontrib><creatorcontrib>Garrido, Jesús</creatorcontrib><creatorcontrib>Lau, Ing Soo</creatorcontrib><creatorcontrib>Rosman, Azmillah</creatorcontrib><creatorcontrib>Naredo, Esperanza</creatorcontrib><creatorcontrib>Carreño, Luis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montoro Alvarez, Maria</au><au>Chong, Ong Yew</au><au>Janta, Iustina</au><au>González, Carlos</au><au>López-Longo, Javier</au><au>Monteagudo, Indalecio</au><au>Valor, Larissa</au><au>Garrido, Jesús</au><au>Lau, Ing Soo</au><au>Rosman, Azmillah</au><au>Naredo, Esperanza</au><au>Carreño, Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>33</volume><issue>2</issue><spage>141</spage><epage>145</epage><pages>141-145</pages><issn>0392-856X</issn><abstract>The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in native complement component levels in RA patients on biologic therapy.
This was a cross-sectional study. Ninety-seven consecutive patients with RA on biologic therapy for at least 3 months were recruited. Clinical, laboratory and Doppler US assessments were performed. The Disease Activity Score in 28 joints (DAS28), Simplified Disease Activity Index (SDAI) and a 12-joint US assessment were carried out. Synovitis was semiquantitatively scored in B-mode and power Doppler (PD) mode.
A significant decrease in native complement (i.e. C3 and C4) and C-reactive protein (CRP) levels was observed. This was highly significant for C3 decrease (p<0.0005), and C4 decrease (p<0.0005). Synovitis detected by PD US showed significant negative association with C3 change (p<0.008), where patients with higher C3 change were more likely to have PD US inactive status on assessment.
Our results suggested that disease inactive status determined by PD US but not by clinical assessment can be related with decrease in complement in RA patients treated with biologic therapy.</abstract><cop>Italy</cop><pmid>25665178</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Biological Products - therapeutic use Biomarkers - blood C-Reactive Protein - metabolism Complement Activation - drug effects Complement System Proteins - metabolism Cross-Sectional Studies Female Humans Inflammation Mediators - blood Male Middle Aged Predictive Value of Tests Remission Induction Severity of Illness Index Synovial Membrane - diagnostic imaging Synovial Membrane - drug effects Synovial Membrane - immunology Synovitis - diagnostic imaging Synovitis - drug therapy Synovitis - immunology Time Factors Treatment Outcome Ultrasonography, Doppler Young Adult |
| title | Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs |
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