Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications
Background Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients. Objective To evaluate the diagnost...
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| Veröffentlicht in: | Pediatric radiology 2015-04, Vol.45 (5), p.658-666 |
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| creator | Tomita, Hirofumi Fuchimoto, Yasushi Ohkuma, Kiyoshi Hoshino, Ken Fujino, Akihiro Kato, Mototoshi Fujimura, Takumi Ishihama, Hideo Takahashi, Nobuhiro Tanami, Yutaka Nakatsuka, Seishi Ebinuma, Hirotoshi Saito, Hidetsugu Shinoda, Masahiro Kitagawa, Yuko Kuroda, Tatsuo |
| description | Background
Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients.
Objective
To evaluate the diagnostic value of spleen stiffness measurements by acoustic radiation force impulse (ARFI) imaging in diagnosing venous complications after pediatric living donor liver transplantation.
Materials and methods
We prospectively enrolled 69 patients after pediatric living donor liver transplantation using a left-side liver allograft. Around the time of the protocol liver biopsy examination, spleen stiffness measurements by ARFI imaging were performed via the left intercostal space at the center of the spleen parenchyma and repeated five times. Imaging examinations around the time of the spleen stiffness measurements were retrospectively reviewed. Regarding venous complications, significant portal and hepatic venous stenosis was defined as >50% stenosis on multiphasic computed tomography.
Results
After post hoc exclusion, 62 patients were studied. Portal and hepatic venous stenosis was identified in three and two patients, respectively. The median spleen stiffness values were 2.70 and 4.00 m/s in patients without and with venous complications, respectively (
P
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| doi_str_mv | 10.1007/s00247-014-3215-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1674960666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3915210581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-e76714baf650c3eeceeae7959a5213b300af162c088dc14df5ef14f35774e3be3</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhSMEopfCA7BBltiwCYzjv4QdqviTKrEA1pbjjC-uEju1k6v2yXg9nKYghMTKGs8354x9quo5hdcUQL3JAA1XNVBes4aKWj6oDpSzpqZd1z6sDsCA1sB5d1Y9yfkKAJig7HF11ggBtBHqUP38Oo-IgeTFOxcwZzKhyWvCCcOSSX9LjI1r6VqSzODN4mMgLiaLxE_zOubtNEcfjsS4BRMZ_WkrhhjiXVGulmRCnkcTln3cB2J_-HFIGN4SQ-a4FC9vRnK9FsZv1KnIhgFvNitywlBWIDZO8-jtnUZ-Wj1yprg_uz_Pq-8f3n-7-FRffvn4-eLdZW0FtEuNSirKe-OkAMsQLaJB1YnOiIayngEYR2VjoW0HS_ngBDrKHRNKcWQ9svPq1a47p3i9Yl705LPFsbwGy1KaSsU7CVLKgr78B72KawplO02V4JKxVkCh6E7ZFHNO6PScyg-mW01Bb6nqPVVdUtVbqnpTfnGvvPYTDn8mfsdYgGYHcmmFI6a_rP-r-gua17Kw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1754633850</pqid></control><display><type>article</type><title>Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Tomita, Hirofumi ; Fuchimoto, Yasushi ; Ohkuma, Kiyoshi ; Hoshino, Ken ; Fujino, Akihiro ; Kato, Mototoshi ; Fujimura, Takumi ; Ishihama, Hideo ; Takahashi, Nobuhiro ; Tanami, Yutaka ; Nakatsuka, Seishi ; Ebinuma, Hirotoshi ; Saito, Hidetsugu ; Shinoda, Masahiro ; Kitagawa, Yuko ; Kuroda, Tatsuo</creator><creatorcontrib>Tomita, Hirofumi ; Fuchimoto, Yasushi ; Ohkuma, Kiyoshi ; Hoshino, Ken ; Fujino, Akihiro ; Kato, Mototoshi ; Fujimura, Takumi ; Ishihama, Hideo ; Takahashi, Nobuhiro ; Tanami, Yutaka ; Nakatsuka, Seishi ; Ebinuma, Hirotoshi ; Saito, Hidetsugu ; Shinoda, Masahiro ; Kitagawa, Yuko ; Kuroda, Tatsuo</creatorcontrib><description>Background
Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients.
Objective
To evaluate the diagnostic value of spleen stiffness measurements by acoustic radiation force impulse (ARFI) imaging in diagnosing venous complications after pediatric living donor liver transplantation.
Materials and methods
We prospectively enrolled 69 patients after pediatric living donor liver transplantation using a left-side liver allograft. Around the time of the protocol liver biopsy examination, spleen stiffness measurements by ARFI imaging were performed via the left intercostal space at the center of the spleen parenchyma and repeated five times. Imaging examinations around the time of the spleen stiffness measurements were retrospectively reviewed. Regarding venous complications, significant portal and hepatic venous stenosis was defined as >50% stenosis on multiphasic computed tomography.
Results
After post hoc exclusion, 62 patients were studied. Portal and hepatic venous stenosis was identified in three and two patients, respectively. The median spleen stiffness values were 2.70 and 4.00 m/s in patients without and with venous complications, respectively (
P
< 0.001). Spleen stiffness measurements showed good diagnostic power for venous complications, and the cutoff value was determined as 2.93 m/s, with 100% sensitivity and 78.9% specificity. Spleen stiffness measurements decreased with the relief of venous stenosis resulting from an interventional radiology procedure.
Conclusion
Spleen stiffness measurements by ARFI imaging might provide a useful quantitative index for venous complications after pediatric living donor liver transplantation.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-014-3215-6</identifier><identifier>PMID: 25501257</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Child ; Child, Preschool ; Elasticity Imaging Techniques ; Female ; Humans ; Hypertension, Portal - diagnostic imaging ; Hypertension, Portal - physiopathology ; Imaging ; Liver Transplantation ; Living Donors ; Male ; Medicine ; Medicine & Public Health ; Neuroradiology ; Nuclear Medicine ; Oncology ; Original Article ; Pediatrics ; Postoperative Complications - diagnostic imaging ; Postoperative Complications - physiopathology ; Prospective Studies ; Radiology ; Sensitivity and Specificity ; Spleen - diagnostic imaging ; Spleen - pathology ; Ultrasound</subject><ispartof>Pediatric radiology, 2015-04, Vol.45 (5), p.658-666</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-e76714baf650c3eeceeae7959a5213b300af162c088dc14df5ef14f35774e3be3</citedby><cites>FETCH-LOGICAL-c508t-e76714baf650c3eeceeae7959a5213b300af162c088dc14df5ef14f35774e3be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00247-014-3215-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00247-014-3215-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25501257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomita, Hirofumi</creatorcontrib><creatorcontrib>Fuchimoto, Yasushi</creatorcontrib><creatorcontrib>Ohkuma, Kiyoshi</creatorcontrib><creatorcontrib>Hoshino, Ken</creatorcontrib><creatorcontrib>Fujino, Akihiro</creatorcontrib><creatorcontrib>Kato, Mototoshi</creatorcontrib><creatorcontrib>Fujimura, Takumi</creatorcontrib><creatorcontrib>Ishihama, Hideo</creatorcontrib><creatorcontrib>Takahashi, Nobuhiro</creatorcontrib><creatorcontrib>Tanami, Yutaka</creatorcontrib><creatorcontrib>Nakatsuka, Seishi</creatorcontrib><creatorcontrib>Ebinuma, Hirotoshi</creatorcontrib><creatorcontrib>Saito, Hidetsugu</creatorcontrib><creatorcontrib>Shinoda, Masahiro</creatorcontrib><creatorcontrib>Kitagawa, Yuko</creatorcontrib><creatorcontrib>Kuroda, Tatsuo</creatorcontrib><title>Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Background
Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients.
Objective
To evaluate the diagnostic value of spleen stiffness measurements by acoustic radiation force impulse (ARFI) imaging in diagnosing venous complications after pediatric living donor liver transplantation.
Materials and methods
We prospectively enrolled 69 patients after pediatric living donor liver transplantation using a left-side liver allograft. Around the time of the protocol liver biopsy examination, spleen stiffness measurements by ARFI imaging were performed via the left intercostal space at the center of the spleen parenchyma and repeated five times. Imaging examinations around the time of the spleen stiffness measurements were retrospectively reviewed. Regarding venous complications, significant portal and hepatic venous stenosis was defined as >50% stenosis on multiphasic computed tomography.
Results
After post hoc exclusion, 62 patients were studied. Portal and hepatic venous stenosis was identified in three and two patients, respectively. The median spleen stiffness values were 2.70 and 4.00 m/s in patients without and with venous complications, respectively (
P
< 0.001). Spleen stiffness measurements showed good diagnostic power for venous complications, and the cutoff value was determined as 2.93 m/s, with 100% sensitivity and 78.9% specificity. Spleen stiffness measurements decreased with the relief of venous stenosis resulting from an interventional radiology procedure.
Conclusion
Spleen stiffness measurements by ARFI imaging might provide a useful quantitative index for venous complications after pediatric living donor liver transplantation.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Elasticity Imaging Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Portal - diagnostic imaging</subject><subject>Hypertension, Portal - physiopathology</subject><subject>Imaging</subject><subject>Liver Transplantation</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Postoperative Complications - diagnostic imaging</subject><subject>Postoperative Complications - physiopathology</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>Sensitivity and Specificity</subject><subject>Spleen - diagnostic imaging</subject><subject>Spleen - pathology</subject><subject>Ultrasound</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1u1TAQhSMEopfCA7BBltiwCYzjv4QdqviTKrEA1pbjjC-uEju1k6v2yXg9nKYghMTKGs8354x9quo5hdcUQL3JAA1XNVBes4aKWj6oDpSzpqZd1z6sDsCA1sB5d1Y9yfkKAJig7HF11ggBtBHqUP38Oo-IgeTFOxcwZzKhyWvCCcOSSX9LjI1r6VqSzODN4mMgLiaLxE_zOubtNEcfjsS4BRMZ_WkrhhjiXVGulmRCnkcTln3cB2J_-HFIGN4SQ-a4FC9vRnK9FsZv1KnIhgFvNitywlBWIDZO8-jtnUZ-Wj1yprg_uz_Pq-8f3n-7-FRffvn4-eLdZW0FtEuNSirKe-OkAMsQLaJB1YnOiIayngEYR2VjoW0HS_ngBDrKHRNKcWQ9svPq1a47p3i9Yl705LPFsbwGy1KaSsU7CVLKgr78B72KawplO02V4JKxVkCh6E7ZFHNO6PScyg-mW01Bb6nqPVVdUtVbqnpTfnGvvPYTDn8mfsdYgGYHcmmFI6a_rP-r-gua17Kw</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Tomita, Hirofumi</creator><creator>Fuchimoto, Yasushi</creator><creator>Ohkuma, Kiyoshi</creator><creator>Hoshino, Ken</creator><creator>Fujino, Akihiro</creator><creator>Kato, Mototoshi</creator><creator>Fujimura, Takumi</creator><creator>Ishihama, Hideo</creator><creator>Takahashi, Nobuhiro</creator><creator>Tanami, Yutaka</creator><creator>Nakatsuka, Seishi</creator><creator>Ebinuma, Hirotoshi</creator><creator>Saito, Hidetsugu</creator><creator>Shinoda, Masahiro</creator><creator>Kitagawa, Yuko</creator><creator>Kuroda, Tatsuo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications</title><author>Tomita, Hirofumi ; Fuchimoto, Yasushi ; Ohkuma, Kiyoshi ; Hoshino, Ken ; Fujino, Akihiro ; Kato, Mototoshi ; Fujimura, Takumi ; Ishihama, Hideo ; Takahashi, Nobuhiro ; Tanami, Yutaka ; Nakatsuka, Seishi ; Ebinuma, Hirotoshi ; Saito, Hidetsugu ; Shinoda, Masahiro ; Kitagawa, Yuko ; Kuroda, Tatsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-e76714baf650c3eeceeae7959a5213b300af162c088dc14df5ef14f35774e3be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Elasticity Imaging Techniques</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Portal - diagnostic imaging</topic><topic>Hypertension, Portal - physiopathology</topic><topic>Imaging</topic><topic>Liver Transplantation</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Postoperative Complications - diagnostic imaging</topic><topic>Postoperative Complications - physiopathology</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>Sensitivity and Specificity</topic><topic>Spleen - diagnostic imaging</topic><topic>Spleen - pathology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomita, Hirofumi</creatorcontrib><creatorcontrib>Fuchimoto, Yasushi</creatorcontrib><creatorcontrib>Ohkuma, Kiyoshi</creatorcontrib><creatorcontrib>Hoshino, Ken</creatorcontrib><creatorcontrib>Fujino, Akihiro</creatorcontrib><creatorcontrib>Kato, Mototoshi</creatorcontrib><creatorcontrib>Fujimura, Takumi</creatorcontrib><creatorcontrib>Ishihama, Hideo</creatorcontrib><creatorcontrib>Takahashi, Nobuhiro</creatorcontrib><creatorcontrib>Tanami, Yutaka</creatorcontrib><creatorcontrib>Nakatsuka, Seishi</creatorcontrib><creatorcontrib>Ebinuma, Hirotoshi</creatorcontrib><creatorcontrib>Saito, Hidetsugu</creatorcontrib><creatorcontrib>Shinoda, Masahiro</creatorcontrib><creatorcontrib>Kitagawa, Yuko</creatorcontrib><creatorcontrib>Kuroda, Tatsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomita, Hirofumi</au><au>Fuchimoto, Yasushi</au><au>Ohkuma, Kiyoshi</au><au>Hoshino, Ken</au><au>Fujino, Akihiro</au><au>Kato, Mototoshi</au><au>Fujimura, Takumi</au><au>Ishihama, Hideo</au><au>Takahashi, Nobuhiro</au><au>Tanami, Yutaka</au><au>Nakatsuka, Seishi</au><au>Ebinuma, Hirotoshi</au><au>Saito, Hidetsugu</au><au>Shinoda, Masahiro</au><au>Kitagawa, Yuko</au><au>Kuroda, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications</atitle><jtitle>Pediatric radiology</jtitle><stitle>Pediatr Radiol</stitle><addtitle>Pediatr Radiol</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>45</volume><issue>5</issue><spage>658</spage><epage>666</epage><pages>658-666</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Background
Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients.
Objective
To evaluate the diagnostic value of spleen stiffness measurements by acoustic radiation force impulse (ARFI) imaging in diagnosing venous complications after pediatric living donor liver transplantation.
Materials and methods
We prospectively enrolled 69 patients after pediatric living donor liver transplantation using a left-side liver allograft. Around the time of the protocol liver biopsy examination, spleen stiffness measurements by ARFI imaging were performed via the left intercostal space at the center of the spleen parenchyma and repeated five times. Imaging examinations around the time of the spleen stiffness measurements were retrospectively reviewed. Regarding venous complications, significant portal and hepatic venous stenosis was defined as >50% stenosis on multiphasic computed tomography.
Results
After post hoc exclusion, 62 patients were studied. Portal and hepatic venous stenosis was identified in three and two patients, respectively. The median spleen stiffness values were 2.70 and 4.00 m/s in patients without and with venous complications, respectively (
P
< 0.001). Spleen stiffness measurements showed good diagnostic power for venous complications, and the cutoff value was determined as 2.93 m/s, with 100% sensitivity and 78.9% specificity. Spleen stiffness measurements decreased with the relief of venous stenosis resulting from an interventional radiology procedure.
Conclusion
Spleen stiffness measurements by ARFI imaging might provide a useful quantitative index for venous complications after pediatric living donor liver transplantation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25501257</pmid><doi>10.1007/s00247-014-3215-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pediatric radiology, 2015-04, Vol.45 (5), p.658-666 |
| issn | 0301-0449 1432-1998 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Child Child, Preschool Elasticity Imaging Techniques Female Humans Hypertension, Portal - diagnostic imaging Hypertension, Portal - physiopathology Imaging Liver Transplantation Living Donors Male Medicine Medicine & Public Health Neuroradiology Nuclear Medicine Oncology Original Article Pediatrics Postoperative Complications - diagnostic imaging Postoperative Complications - physiopathology Prospective Studies Radiology Sensitivity and Specificity Spleen - diagnostic imaging Spleen - pathology Ultrasound |
| title | Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications |
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