Change in tropism upon immune escape by human immunodeficiency virus

The V3 loop of human immunodeficiency virus type 1 is both a determinant of viral cell tropism and a target for neutralizing antibodies. This relationship was investigated. Selection of a dual tropic (T cells and macrophages) virus to replicate in CD4+ brain cells results in loss of macrophage tropi...

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Veröffentlicht in:	Journal of Virology 1995-05, Vol.69 (5), p.3167-3170
Hauptverfasser:	McKnight, A. (Institute of Cancer Research, London, UK.), Weiss, R.A, Shotton, C, Takeuchi, Y, Hoshino, H, Clapham, P.R
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Antibodies, Monoclonal Antigenic Variation - genetics ARN MENSAJERO ARN MESSAGER Brain - cytology Brain - immunology Brain - virology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cells, Cultured Cloning, Molecular CORONAVIRIDAE EXPRESION GENICA EXPRESSION DES GENES GENE GENES HIV Antibodies HIV Antigens - genetics HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Seropositivity - immunology HIV Seropositivity - virology HIV-1 - immunology HIV-1 - pathogenicity HIV-1 - physiology human immunodeficiency virus 1 Humans Macrophages - immunology Macrophages - virology Molecular Sequence Data Neutralization Tests Organ Specificity Peptide Fragments - genetics Peptide Fragments - immunology SECUENCIA NUCLEICA SEQUENCE NUCLEIQUE VARIACION GENETICA VARIATION GENETIQUE Virus Replication - immunology
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