Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors

Prolactin (PRL) has recently been demonstrated to induce tyrosine phosphorylation and activation of the cytoplasmic tyrosine kinase JAK2 in PRL-dependent Nb2 lymphoma cells. The present study represents an initial effort to identify cytoplasmic regions of the PRL receptor (PRLR) that are critical to...

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Veröffentlicht in:	The Journal of biological chemistry 1994-07, Vol.269 (28), p.18267-18270
Hauptverfasser:	DASILVA, L, HOWARD, O. M. Z, RUI, H, KIRKEN, R. A, FARRAR, W. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cell Division - drug effects Cell Line Cell Membrane - metabolism Cell receptors Cell structures and functions DNA Primers Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Interleukin-3 - pharmacology Janus Kinase 2 Mice Molecular and cellular biology Molecular Sequence Data Mutagenesis Ornithine Decarboxylase - biosynthesis Plasmids Polymerase Chain Reaction Prolactin - pharmacology Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Rats Receptors, Prolactin - biosynthesis Receptors, Prolactin - drug effects Receptors, Prolactin - physiology Restriction Mapping RNA, Messenger - biosynthesis Sequence Deletion Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Signal Transduction Transfection
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