The effect of chlorinated paraffins on hepatic enzymes and thyroid hormones

Male rats and mice were administered chlorinated paraffins (CPs) by daily gavage in corn oil for 14 days. Chlorowax 500C (short chain CP with 58% chlorination), Cereclor 56L (short chain CP with 56% chlorination) and Chlorparaffin 40G (medium chain CP with 40% chlorination) were the CPs studied at d...

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Veröffentlicht in:	Toxicology (Amsterdam) 1993-01, Vol.77 (1), p.81-90
Hauptverfasser:	Wyatt, I., Coutss, C.T., Elcombe, C.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight - drug effects Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chlorinated paraffins Dose-Response Relationship, Drug Hepatic peroxisome proliferation Hydrocarbons, Chlorinated - administration & dosage Hydrocarbons, Chlorinated - toxicity Liver - enzymology Male Medical sciences Mice Mice, Inbred Strains Microbodies - drug effects Organ Size - drug effects Paraffin - analogs & derivatives Paraffin - toxicity Rats Rats, Sprague-Dawley Thyroid Thyrotropin - blood Thyroxine - blood Tumors
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